HCSGD entry for PCBP4
1. General information
| Official gene symbol | PCBP4 |
|---|---|
| Entrez ID | 57060 |
| Gene full name | poly(rC) binding protein 4 |
| Other gene symbols | CBP LIP4 MCG10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IDA IEA NAS | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | IDA | biological_process |
| GO:0007050 | Cell cycle arrest | IDA | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IDA | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9293862011 | 0.0283110900 | 0.9999902473 | 0.3205001287 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1906299855 |
| GSE13712_SHEAR | Down | -0.0428444572 |
| GSE13712_STATIC | Up | 0.0109275391 |
| GSE19018 | Up | 0.1694728752 |
| GSE19899_A1 | Down | -0.6097591123 |
| GSE19899_A2 | Up | 0.4916131278 |
| PubMed_21979375_A1 | Down | -0.2433117612 |
| PubMed_21979375_A2 | Down | -0.4430475798 |
| GSE35957 | Up | 0.1252872911 |
| GSE36640 | Up | 0.1512744912 |
| GSE54402 | Down | -0.0764790733 |
| GSE9593 | Down | -0.1990592851 |
| GSE43922 | Down | -0.2199231810 |
| GSE24585 | Up | 0.0885065416 |
| GSE37065 | Down | -0.2963210155 |
| GSE28863_A1 | Down | -0.3559832772 |
| GSE28863_A2 | Down | -0.5624979657 |
| GSE28863_A3 | Down | -0.4742958235 |
| GSE28863_A4 | Down | -0.2723841096 |
| GSE48662 | Up | 0.2026492340 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26915821 | Poly(C)-binding protein 4 (PCBP4), also called MCG10 and a target of p53, plays a role in the cell cycle and is implicated in lung tumor suppression |
| 26915821 | We also found that p53 expression is markedly reduced in PCBP4-deficient MEFs and mouse tissues, suggesting that PCBP4 in turn regulates p53 expression |
| 26915821 | To determine how PCBP4 regulates p53 expression, PCBP4 targets were identified by RNA immunoprecipitation followed by RNA sequencing (RNA-seq) |
| 26915821 | We found that the transcript encoding ZFP871 (zinc finger protein 871; also called ZNF709 in humans) interacts with and is regulated by PCBP4 via mRNA stability |
| 26915821 | Moreover, loss of ZFP871 reverses the reduction of p53 expression by lack of PCBP4, and thus increased expression of ZFP871 is responsible for decreased expression of p53 in the PCBP4-deficient MEFs and mouse tissues |
| 26915821 | Interestingly, we found that, like PCBP4, ZFP871 is also regulated by DNA damage and p53 |
| 26915821 | Together, we hypothesize that PCBP4 is a potential tissue-specific tumor suppressor and that ZFP871 is part of MDM2 and possibly other ubiquitin E3 ligases that target p53 for degradation |
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