HCSGD entry for PTGIS

1. General information

Official gene symbolPTGIS
Entrez ID5740
Gene full nameprostaglandin I2 (prostacyclin) synthase
Other gene symbolsCYP8 CYP8A1 PGIS PTGI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001516Prostaglandin biosynthetic processIDAbiological_process
GO:0004497Monooxygenase activityIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceISScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005901CaveolaIDAcellular_component
GO:0006690Icosanoid metabolic processTASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008116Prostaglandin-I synthase activityIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019371Cyclooxygenase pathwayTASbiological_process
GO:0020037Heme bindingIDAmolecular_function
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0035360Positive regulation of peroxisome proliferator activated receptor signaling pathwayIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045019Negative regulation of nitric oxide biosynthetic processIDAbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0050728Negative regulation of inflammatory responseIDAbiological_process
GO:0071347Cellular response to interleukin-1IEPbiological_process
GO:0071354Cellular response to interleukin-6IEPbiological_process
GO:0071456Cellular response to hypoxiaIDAbiological_process
GO:0097190Apoptotic signaling pathwayIDAbiological_process
GO:1900119Positive regulation of execution phase of apoptosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46093279130.00156854220.99999024730.0761726937

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.5527397567
GSE13712_SHEARDown-1.1571864492
GSE13712_STATICDown-0.5395854715
GSE19018Down-2.2562279347
GSE19899_A1Down-0.0144416093
GSE19899_A2Down-0.1521654433
PubMed_21979375_A1Down-0.0478123468
PubMed_21979375_A2Down-0.0466054500
GSE35957Up0.7445425791
GSE36640Down-1.3819392454
GSE54402Down-3.3949079453
GSE9593Down-0.1703744977
GSE43922Down-0.0586125936
GSE24585Up0.0661674019
GSE37065Down-0.1298151351
GSE28863_A1Up0.3038735041
GSE28863_A2Up1.1114089174
GSE28863_A3Down-0.7319664211
GSE28863_A4Up0.0618454044
GSE48662Up0.8054386071

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhenylbutazoneDB00812 APRD00409 | DB08343
EpoprostenolDB01240 APRD00949
(6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACIDDB08675 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.