HCSGD entry for HECW2
1. General information
| Official gene symbol | HECW2 |
|---|---|
| Entrez ID | 57520 |
| Gene full name | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 |
| Other gene symbols | NEDL2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IBA | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0042787 | Protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0064434292 | 0.9519335436 | 0.2116718905 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3053108512 |
| GSE13712_SHEAR | Up | 0.5648732294 |
| GSE13712_STATIC | Up | 0.2111573801 |
| GSE19018 | Up | 0.2027069922 |
| GSE19899_A1 | Up | 0.2461531618 |
| GSE19899_A2 | Up | 0.4838391253 |
| PubMed_21979375_A1 | Down | -0.0121446555 |
| PubMed_21979375_A2 | Up | 0.6431560799 |
| GSE35957 | Up | 0.4885283934 |
| GSE36640 | Up | 1.1438693884 |
| GSE54402 | Up | 0.2165300255 |
| GSE9593 | Up | 0.6664356298 |
| GSE43922 | Down | -0.1463221949 |
| GSE24585 | Up | 0.1055409256 |
| GSE37065 | Up | 0.1480733206 |
| GSE28863_A1 | Up | 0.2853596475 |
| GSE28863_A2 | Up | 0.9494784711 |
| GSE28863_A3 | Down | -0.2949971159 |
| GSE28863_A4 | Down | -0.0965579908 |
| GSE48662 | Up | 0.2672299401 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023380 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
