HCSGD entry for CHD8
1. General information
| Official gene symbol | CHD8 |
|---|---|
| Entrez ID | 57680 |
| Gene full name | chromodomain helicase DNA binding protein 8 |
| Other gene symbols | AUTS18 HELSNF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0002039 | P53 binding | ISS | molecular_function |
| GO:0003677 | DNA binding | IEA IMP | molecular_function |
| GO:0003678 | DNA helicase activity | IMP | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008013 | Beta-catenin binding | IDA | molecular_function |
| GO:0008094 | DNA-dependent ATPase activity | IDA | molecular_function |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IDA | biological_process |
| GO:0032508 | DNA duplex unwinding | IMP | biological_process |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0042393 | Histone binding | ISS | molecular_function |
| GO:0043044 | ATP-dependent chromatin remodeling | IMP | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0045945 | Positive regulation of transcription from RNA polymerase III promoter | IMP | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IDA | biological_process |
| GO:0070016 | Armadillo repeat domain binding | IEA | molecular_function |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
| GO:2000270 | Negative regulation of fibroblast apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0322162000 | 0.8727269595 | 0.4142465071 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1363662030 |
| GSE13712_SHEAR | Up | 0.1515466357 |
| GSE13712_STATIC | Up | 0.1295460837 |
| GSE19018 | Down | -0.2163737953 |
| GSE19899_A1 | Up | 0.0898842912 |
| GSE19899_A2 | Up | 0.2115358542 |
| PubMed_21979375_A1 | Up | 0.3518500441 |
| PubMed_21979375_A2 | Up | 1.2338349146 |
| GSE35957 | Down | -0.3226342629 |
| GSE36640 | Down | -0.3497670337 |
| GSE54402 | Up | 0.1132708673 |
| GSE9593 | Down | -0.3574911148 |
| GSE43922 | Up | 0.0011292152 |
| GSE24585 | Up | 0.3776617707 |
| GSE37065 | Up | 0.1928020714 |
| GSE28863_A1 | Up | 1.1694633825 |
| GSE28863_A2 | Up | 0.8944823731 |
| GSE28863_A3 | Down | -0.0576934152 |
| GSE28863_A4 | Up | 0.0189019611 |
| GSE48662 | Up | 0.2549037799 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT030570 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036108 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037268 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038139 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039940 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
