HCSGD entry for PTPN1
1. General information
| Official gene symbol | PTPN1 |
|---|---|
| Entrez ID | 5770 |
| Gene full name | protein tyrosine phosphatase, non-receptor type 1 |
| Other gene symbols | PTP1B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004725 | Protein tyrosine phosphatase activity | IDA IEA TAS | molecular_function |
| GO:0005158 | Insulin receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0008286 | Insulin receptor signaling pathway | IEA | biological_process |
| GO:0009966 | Regulation of signal transduction | IMP | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030100 | Regulation of endocytosis | IDA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | IDA | biological_process |
| GO:0030971 | Receptor tyrosine kinase binding | IPI | molecular_function |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0031532 | Actin cytoskeleton reorganization | IMP | biological_process |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | IDA IMP | biological_process |
| GO:0035791 | Platelet-derived growth factor receptor-beta signaling pathway | IEA IMP | biological_process |
| GO:0046626 | Regulation of insulin receptor signaling pathway | IEA | biological_process |
| GO:0046627 | Negative regulation of insulin receptor signaling pathway | NAS | biological_process |
| GO:0046875 | Ephrin receptor binding | IPI | molecular_function |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060334 | Regulation of interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
| GO:0060338 | Regulation of type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | TAS | biological_process |
| GO:1902202 | Regulation of hepatocyte growth factor receptor signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0936217279 | 0.9682385092 | 0.6410990375 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0511946513 |
| GSE13712_SHEAR | Up | 0.3413244149 |
| GSE13712_STATIC | Up | 0.2301125584 |
| GSE19018 | Down | -0.1368207499 |
| GSE19899_A1 | Up | 0.1976538292 |
| GSE19899_A2 | Up | 0.1947549295 |
| PubMed_21979375_A1 | Up | 0.0855942622 |
| PubMed_21979375_A2 | Up | 0.4944454011 |
| GSE35957 | Up | 0.0700401842 |
| GSE36640 | Down | -0.3005510727 |
| GSE54402 | Up | 0.3900048873 |
| GSE9593 | Up | 0.1459435858 |
| GSE43922 | Up | 0.4421872971 |
| GSE24585 | Up | 0.1376143691 |
| GSE37065 | Up | 0.0258568641 |
| GSE28863_A1 | Up | 0.1720605366 |
| GSE28863_A2 | Down | -0.0426070307 |
| GSE28863_A3 | Down | -0.1638817218 |
| GSE28863_A4 | Up | 0.0355264799 |
| GSE48662 | Up | 0.3614043916 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003154 | 2DGE//immunoprecipitaion//Luciferase reporter assay//Mass spectrometry//Microarray//qRT-PCR//Western blot | Functional MTI | 19826008 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT007007 | Luciferase reporter assay | Functional MTI | 22807119 |
| hsa-miR-362-3p | MIMAT0004683 | MIRT007351 | Western blot | Functional MTI | 23280316 |
| hsa-miR-375 | MIMAT0000728 | MIRT019939 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-1 | MIMAT0000416 | MIRT023987 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029981 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25341065 | This activation required functionally active A1AT protein and protein tyrosine phosphatase 1B expression |
| 15039022 | Phosphotyrosine phosphatases acting on band 3 in human erythrocytes of different age: PTP1B processing during cell ageing |
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