HCSGD entry for MARK4
1. General information
| Official gene symbol | MARK4 |
|---|---|
| Entrez ID | 57787 |
| Gene full name | MAP/microtubule affinity-regulating kinase 4 |
| Other gene symbols | MARK4L MARK4S MARKL1 MARKL1L |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000226 | Microtubule cytoskeleton organization | IMP | biological_process |
| GO:0001578 | Microtubule bundle formation | IEP | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA NAS | molecular_function |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007399 | Nervous system development | IDA | biological_process |
| GO:0008017 | Microtubule binding | IDA | molecular_function |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0043005 | Neuron projection | IDA | cellular_component |
| GO:0043015 | Gamma-tubulin binding | IDA | molecular_function |
| GO:0043068 | Positive regulation of programmed cell death | NAS | biological_process |
| GO:0043130 | Ubiquitin binding | NAS | molecular_function |
| GO:0050321 | Tau-protein kinase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0160781543 | 0.9492467156 | 0.3127402214 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3065846544 |
| GSE13712_SHEAR | Down | -0.4617616011 |
| GSE13712_STATIC | Down | -0.1610331057 |
| GSE19018 | Up | 0.0528190988 |
| GSE19899_A1 | Up | 0.2245647413 |
| GSE19899_A2 | Up | 1.1041084935 |
| PubMed_21979375_A1 | Up | 1.1056198673 |
| PubMed_21979375_A2 | Up | 1.3346266812 |
| GSE35957 | Up | 0.1962178371 |
| GSE36640 | Up | 0.8951345108 |
| GSE54402 | Up | 0.3979838576 |
| GSE9593 | Up | 0.6843791469 |
| GSE43922 | Up | 0.1536419406 |
| GSE24585 | Down | -0.2428542951 |
| GSE37065 | Down | -0.2161894759 |
| GSE28863_A1 | Up | 0.0245591778 |
| GSE28863_A2 | Up | 0.0089313789 |
| GSE28863_A3 | Up | 0.2590207560 |
| GSE28863_A4 | Up | 0.0039491327 |
| GSE48662 | Up | 0.1820804251 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018631 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047961 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22833545 | Comparative proteomics analysis revealed 24 differentially secreted protein spots including Raf kinase inhibitor protein (RKIP), alpha-Enolase, AKAP9, and MARK4, and the findings were confirmed by Western blot analysis of IR-induced senescent cancer cells |
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