HCSGD entry for PTPRK
1. General information
| Official gene symbol | PTPRK |
|---|---|
| Entrez ID | 5796 |
| Gene full name | protein tyrosine phosphatase, receptor type, K |
| Other gene symbols | R-PTP-kappa |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001750 | Photoreceptor outer segment | IEA | cellular_component |
| GO:0004725 | Protein tyrosine phosphatase activity | IDA IEA | molecular_function |
| GO:0005001 | Transmembrane receptor protein tyrosine phosphatase activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005887 | Integral component of plasma membrane | NAS | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0005912 | Adherens junction | IEA | cellular_component |
| GO:0006470 | Protein dephosphorylation | IDA | biological_process |
| GO:0007155 | Cell adhesion | IMP | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0008013 | Beta-catenin binding | IPI | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010839 | Negative regulation of keratinocyte proliferation | IDA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0016477 | Cell migration | IMP | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030336 | Negative regulation of cell migration | IDA | biological_process |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0031256 | Leading edge membrane | IDA | cellular_component |
| GO:0034394 | Protein localization to cell surface | IDA | biological_process |
| GO:0034614 | Cellular response to reactive oxygen species | IDA | biological_process |
| GO:0034644 | Cellular response to UV | IDA | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0045295 | Gamma-catenin binding | IPI | molecular_function |
| GO:0045786 | Negative regulation of cell cycle | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048041 | Focal adhesion assembly | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1376770297 | 0.3832054253 | 0.7474480305 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6963529575 |
| GSE13712_SHEAR | Down | -0.0205911051 |
| GSE13712_STATIC | Up | 0.3759746869 |
| GSE19018 | Down | -0.2814383430 |
| GSE19899_A1 | Down | -0.0970528626 |
| GSE19899_A2 | Down | -0.1131722327 |
| PubMed_21979375_A1 | Down | -0.4683307297 |
| PubMed_21979375_A2 | Up | 0.1072565053 |
| GSE35957 | Down | -0.4091645636 |
| GSE36640 | Up | 1.2381548189 |
| GSE54402 | Up | 0.1081843397 |
| GSE9593 | Up | 0.4031032351 |
| GSE43922 | Up | 0.0032048671 |
| GSE24585 | Down | -0.2108146882 |
| GSE37065 | Down | -0.2401392743 |
| GSE28863_A1 | Up | 0.0450831344 |
| GSE28863_A2 | Up | 0.5469867371 |
| GSE28863_A3 | Down | -0.3274621283 |
| GSE28863_A4 | Down | -0.2503462247 |
| GSE48662 | Up | 0.5719005767 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005161 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-133b | MIMAT0000770 | MIRT007126 | Luciferase reporter assay | Functional MTI | 23451058 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021457 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-935 | MIMAT0004978 | MIRT036651 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037091 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039631 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042465 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045592 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
