HCSGD entry for BARD1
1. General information
| Official gene symbol | BARD1 |
|---|---|
| Entrez ID | 580 |
| Gene full name | BRCA1 associated RING domain 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | NAS | cellular_component |
| GO:0001894 | Tissue homeostasis | TAS | biological_process |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IMP | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | NAS | biological_process |
| GO:0007050 | Cell cycle arrest | NAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016567 | Protein ubiquitination | NAS | biological_process |
| GO:0019900 | Kinase binding | NAS | molecular_function |
| GO:0031436 | BRCA1-BARD1 complex | IDA | cellular_component |
| GO:0031441 | Negative regulation of mRNA 3'-end processing | NAS | biological_process |
| GO:0042325 | Regulation of phosphorylation | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IMP | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0045732 | Positive regulation of protein catabolic process | NAS | biological_process |
| GO:0046826 | Negative regulation of protein export from nucleus | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0070531 | BRCA1-A complex | IDA | cellular_component |
| GO:0085020 | Protein K6-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9983150108 | 0.0000233540 | 0.9999902473 | 0.0085375000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7137575736 |
| GSE13712_SHEAR | Down | -0.6570268950 |
| GSE13712_STATIC | Down | -0.5248498957 |
| GSE19018 | Down | -0.5756317328 |
| GSE19899_A1 | Down | -0.6928401625 |
| GSE19899_A2 | Down | -3.8509517708 |
| PubMed_21979375_A1 | Down | -2.3259496890 |
| PubMed_21979375_A2 | Down | -3.7486556873 |
| GSE35957 | Down | -2.1417585917 |
| GSE36640 | Down | -3.1406735445 |
| GSE54402 | Down | -0.9585354364 |
| GSE9593 | Down | -1.2240526096 |
| GSE43922 | Down | -2.5236698501 |
| GSE24585 | Up | 0.3043374048 |
| GSE37065 | Up | 0.0382325102 |
| GSE28863_A1 | Down | -0.1556556090 |
| GSE28863_A2 | Up | 0.0492636808 |
| GSE28863_A3 | Down | -0.8759018231 |
| GSE28863_A4 | Down | -0.1172795731 |
| GSE48662 | Down | -1.4729106375 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004138 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004138 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016283 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024951 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
