HCSGD entry for WFDC1
1. General information
| Official gene symbol | WFDC1 |
|---|---|
| Entrez ID | 58189 |
| Gene full name | WAP four-disulfide core domain 1 |
| Other gene symbols | PS20 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | NAS | cellular_component |
| GO:0030308 | Negative regulation of cell growth | NAS | biological_process |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0050680 | Negative regulation of epithelial cell proliferation | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3715092968 | 0.0000475970 | 0.9999902473 | 0.0114692982 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1348987375 |
| GSE13712_SHEAR | Down | -0.5903364287 |
| GSE13712_STATIC | Down | -0.1078117602 |
| GSE19018 | Down | -3.8052315401 |
| GSE19899_A1 | Down | -4.7275313403 |
| GSE19899_A2 | Down | -1.3467481502 |
| PubMed_21979375_A1 | Down | -2.4840034308 |
| PubMed_21979375_A2 | Down | -3.8165446576 |
| GSE35957 | Down | -1.7328690016 |
| GSE36640 | Up | 4.3925273616 |
| GSE54402 | Down | -2.9562417188 |
| GSE9593 | Down | -0.7211523111 |
| GSE43922 | Down | -0.2764989044 |
| GSE24585 | Up | 0.1503013192 |
| GSE37065 | Down | -0.1358319259 |
| GSE28863_A1 | Down | -0.3244469673 |
| GSE28863_A2 | Down | -1.3896789430 |
| GSE28863_A3 | Up | 0.3782987769 |
| GSE28863_A4 | Up | 0.1725947520 |
| GSE48662 | Up | 0.3400694768 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18842679 | Modulated expression of WFDC1 during carcinogenesis and cellular senescence |
| 18842679 | We focused on whey acidic protein four-disulfide core domain 1 (WFDC1), a known secreted protease inhibitor, and found it to be downregulated in the CAFs |
| 18842679 | WFDC1 expression was also dramatically downregulated in highly prolific mesenchymal cells and in various cancers including fibrosarcomas and in tumors of the lung, bladder and brain |
| 18842679 | Overexpression of WFDC1 inhibited the growth rate of the fibrosarcoma HT1080 cell line |
| 18842679 | Furthermore, WFDC1 level was upregulated in senescent fibroblasts |
| 18842679 | Taken together, our data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells |
| 18842679 | Finally, we suggest that the downregulation of WFDC1 might serve as a biomarker for cellular transformation |
Entries Per Page
Displaying Page of
