HCSGD entry for CXCL16

1. General information

Official gene symbolCXCL16
Entrez ID58191
Gene full namechemokine (C-X-C motif) ligand 16
Other gene symbolsCXCLG16 SR-PSOX SRPSOX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005041Low-density lipoprotein receptor activityIEA ISSmolecular_function
GO:0005044Scavenger receptor activityIEA TASmolecular_function
GO:0005102Receptor bindingNASmolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006898Receptor-mediated endocytosisNASbiological_process
GO:0006935ChemotaxisNASbiological_process
GO:0008009Chemokine activityIDA IEA ISSmolecular_function
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneNAScellular_component
GO:0030307Positive regulation of cell growthIEA IMPbiological_process
GO:0030335Positive regulation of cell migrationIEA IMPbiological_process
GO:0034097Response to cytokineIDAbiological_process
GO:0034341Response to interferon-gammaIDA IEAbiological_process
GO:0034612Response to tumor necrosis factorIDA IEAbiological_process
GO:0048247Lymphocyte chemotaxisIEA NASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09408457130.19536131230.64280877010.8564465523

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0544142290
GSE13712_SHEARUp0.2396014350
GSE13712_STATICUp0.4303919981
GSE19018Up0.0672315244
GSE19899_A1Up0.1300967507
GSE19899_A2Up0.1558312748
PubMed_21979375_A1Up0.5722652641
PubMed_21979375_A2Up0.0354356902
GSE35957Down-1.5705567745
GSE36640Up0.5084267774
GSE54402Down-0.4236913291
GSE9593Down-1.8580325355
GSE43922Up0.0137500677
GSE24585Down-0.0366032918
GSE37065Up0.7325937805
GSE28863_A1Up0.3113611391
GSE28863_A2Up0.1631053351
GSE28863_A3Up0.3751357068
GSE28863_A4Down-0.1741173292
GSE48662Up0.5725740090

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019098MicroarrayFunctional MTI (Weak)18185580
hsa-miR-744-5pMIMAT0004945MIRT037621CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049831CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26272362The chemokine CXCL16 and its receptor, C-X-C chemokine receptor (CXCR6), affect tumor progression through different pathways, including leukocyte recruitment and function, cellular senescence, tumor cell proliferation, survival, invasion, and metastasis
26272362We examined how the expression of CXCL16/CXCR6 in prostate cancer (PC) was related to clinicopathological features and activation of inflammatory cells
26272362Immunohistochemistry was used to evaluate the expression of CXCL16/CXCR6, CD3(+) T cells (CD4(+), CD8(+)), and CD20(+) B cells
26272362High expression levels of CXCL16 [hazard ratio (HR), 2
26272362As a conclusion, high protein expression of CXCL16 and high protein co-expression of CXCL16/CXCR6 in PC were independent predictors for a worse clinical outcome
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