HCSGD entry for KMT2C
1. General information
| Official gene symbol | KMT2C |
|---|---|
| Entrez ID | 58508 |
| Gene full name | lysine (K)-specific methyltransferase 2C |
| Other gene symbols | HALR MLL3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008168 | Methyltransferase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016571 | Histone methylation | IEA | biological_process |
| GO:0018022 | Peptidyl-lysine methylation | IDA | biological_process |
| GO:0034968 | Histone lysine methylation | IDA | biological_process |
| GO:0035097 | Histone methyltransferase complex | IDA | cellular_component |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0042800 | Histone methyltransferase activity (H3-K4 specific) | IDA | molecular_function |
| GO:0051568 | Histone H3-K4 methylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5555028228 | 0.6323402682 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3779179675 |
| GSE13712_SHEAR | Up | 0.0938682477 |
| GSE13712_STATIC | Up | 0.0283311872 |
| GSE19018 | Up | 0.0742503426 |
| GSE19899_A1 | Down | -0.0637315196 |
| GSE19899_A2 | Up | 0.1480914708 |
| PubMed_21979375_A1 | Down | -0.1170238102 |
| PubMed_21979375_A2 | Up | 0.3162265956 |
| GSE35957 | Up | 0.0640516551 |
| GSE36640 | Down | -0.2436649958 |
| GSE54402 | Down | -0.0350190742 |
| GSE9593 | Down | -0.0608970498 |
| GSE43922 | Down | -0.0171387429 |
| GSE24585 | Up | 0.2554727424 |
| GSE37065 | Up | 0.1352204567 |
| GSE28863_A1 | Down | -0.0419687052 |
| GSE28863_A2 | Up | 0.0248137291 |
| GSE28863_A3 | Up | 0.1696412096 |
| GSE28863_A4 | Up | 0.0420809328 |
| GSE48662 | Up | 0.1887539647 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT016990 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021900 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028951 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-940 | MIMAT0004983 | MIRT036615 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-708-5p | MIMAT0004926 | MIRT037748 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038581 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039471 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040134 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041865 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044506 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045225 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046443 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048165 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
