HCSGD entry for RAD23B
1. General information
| Official gene symbol | RAD23B |
|---|---|
| Entrez ID | 5887 |
| Gene full name | RAD23 homolog B (S. cerevisiae) |
| Other gene symbols | HHR23B HR23B P58 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000502 | Proteasome complex | IEA | cellular_component |
| GO:0000715 | Nucleotide-excision repair, DNA damage recognition | IDA TAS | biological_process |
| GO:0000718 | Nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0003684 | Damaged DNA binding | IEA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | IDA TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0031593 | Polyubiquitin binding | IDA | molecular_function |
| GO:0032434 | Regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0071942 | XPC complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6471621291 | 0.2333675924 | 0.9999902473 | 0.9303593821 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2837159515 |
| GSE13712_SHEAR | Down | -0.0552943342 |
| GSE13712_STATIC | Down | -0.0763900737 |
| GSE19018 | Up | 0.3272150503 |
| GSE19899_A1 | Down | -0.5241256404 |
| GSE19899_A2 | Down | -0.2525544477 |
| PubMed_21979375_A1 | Down | -0.1728712951 |
| PubMed_21979375_A2 | Down | -0.2851628148 |
| GSE35957 | Up | 0.4925898893 |
| GSE36640 | Down | -0.2526008464 |
| GSE54402 | Up | 0.0024092913 |
| GSE9593 | Down | -0.0066065306 |
| GSE43922 | Down | -0.4094367181 |
| GSE24585 | Down | -0.1321533939 |
| GSE37065 | Down | -0.1377860291 |
| GSE28863_A1 | Up | 0.0837973214 |
| GSE28863_A2 | Up | 0.1708542456 |
| GSE28863_A3 | Up | 0.5302776609 |
| GSE28863_A4 | Up | 0.1120343589 |
| GSE48662 | Up | 0.2233400378 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT000056 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19141645 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005172 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT021032 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035963 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044281 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048119 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048344 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048988 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24823364 | RNA interference-mediated knockdown of hnRNPA3 and, to a lesser extent, RAD23B mirrored the senescent phenotype induced by miR-494 overexpression, blunting cell proliferation and causing up-regulation of SA-beta-galactosidase and DNA damage |
| 24823364 | Ectopic expression of hnRNPA3 or RAD23B slowed the appearance of the senescent phenotype induced by miR-494 |
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