HCSGD entry for RAF1
1. General information
| Official gene symbol | RAF1 |
|---|---|
| Entrez ID | 5894 |
| Gene full name | v-raf-1 murine leukemia viral oncogene homolog 1 |
| Other gene symbols | CRAF NS5 Raf-1 c-Raf |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0000186 | Activation of MAPKK activity | TAS | biological_process |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0005057 | Receptor signaling protein activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IPI | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007190 | Activation of adenylate cyclase activity | NAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0017016 | Ras GTPase binding | IEA | molecular_function |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031143 | Pseudopodium | IEA | cellular_component |
| GO:0031333 | Negative regulation of protein complex assembly | IDA | biological_process |
| GO:0031434 | Mitogen-activated protein kinase kinase binding | IEA | molecular_function |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0035023 | Regulation of Rho protein signal transduction | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0042060 | Wound healing | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042981 | Regulation of apoptotic process | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045104 | Intermediate filament cytoskeleton organization | IEA | biological_process |
| GO:0045595 | Regulation of cell differentiation | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0071550 | Death-inducing signaling complex assembly | IEA | biological_process |
| GO:1902042 | Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | IEA | biological_process |
| GO:2000145 | Regulation of cell motility | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9715937654 | 0.0770550511 | 0.9999902473 | 0.5246384894 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3427277012 |
| GSE13712_SHEAR | Up | 0.1632402246 |
| GSE13712_STATIC | Down | -0.1509267296 |
| GSE19018 | Down | -0.0966358838 |
| GSE19899_A1 | Down | -0.1952635553 |
| GSE19899_A2 | Down | -0.1471411639 |
| PubMed_21979375_A1 | Down | -0.7344051061 |
| PubMed_21979375_A2 | Up | 0.0081471035 |
| GSE35957 | Down | -0.1551696686 |
| GSE36640 | Down | -0.3300447617 |
| GSE54402 | Down | -0.1525904734 |
| GSE9593 | Down | -0.0799726503 |
| GSE43922 | Down | -0.0243869535 |
| GSE24585 | Up | 0.2518709488 |
| GSE37065 | Up | 0.0710180398 |
| GSE28863_A1 | Down | -0.0120207486 |
| GSE28863_A2 | Down | -0.1244076961 |
| GSE28863_A3 | Down | -0.3434137555 |
| GSE28863_A4 | Down | -0.1697960853 |
| GSE48662 | Down | -0.2228344775 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Sorafenib | DB00398 | APRD01304 | DB07438 |
| LErafAON | DB04973 | - |
| XL281 | DB05190 | - |
| iCo-007 | DB05268 | - |
| Regorafenib | DB08896 | - |
| Dabrafenib | DB08912 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT004026 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;qRT-PCR;Microarray;Other | Functional MTI | 19073608 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004418 | Western blot//Western blot;Other | Functional MTI | 19825990 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044977 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046343 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | 2 | hsa-miR-7 | 19072608 | |||
| hsa-miR-7-5p | MIMAT0000252 | 1 | hsa-miR-7 | 19072608 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23578198 | Mechanistic investigations indicated that therapy-induced senescence (TIS) following sunitinib treatment mainly attributed to p53/Dec1 signaling activation mediated by Raf-1/NF-kappaB inhibition in vitro |
| 23578198 | Importantly, in vivo study showed tumor growth inhibition and prolonged overall survival were associated with increased p53 and Dec1 expression, decreased Raf-1 and Ki67 staining, and upregulated SA-beta-gal activity after sunitinib treatment |
| 23578198 | Taken together, our findings suggested that sunitinib treatment performance could be attributable to TIS, depending on p53/Dec1 activation via inhibited Raf-1/nuclear factor (NF)-kappaB activity |
| 21881167 | Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells |
| 21881167 | To determine if active Akt-1 and Raf-1 can influence drug-induced senescence, we stably introduced activated DeltaAkt-1(CA) and DeltaRaf-1(CA) into drug-sensitive and doxorubicin-resistant cells |
| 21881167 | Expression of a constitutively-active Raf-1 construct resulted in higher baseline senescence, indicating these cells possessed the ability to undergo oncogene-induced-senescence |
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