HCSGD entry for ACTA2
1. General information
| Official gene symbol | ACTA2 |
|---|---|
| Entrez ID | 59 |
| Gene full name | actin, alpha 2, smooth muscle, aorta |
| Other gene symbols | AAT6 ACTSA MYMY5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0008217 | Regulation of blood pressure | IEA | biological_process |
| GO:0009615 | Response to virus | IEP | biological_process |
| GO:0014829 | Vascular smooth muscle contraction | IEA | biological_process |
| GO:0015629 | Actin cytoskeleton | IEA | cellular_component |
| GO:0030485 | Smooth muscle contractile fiber | IEA | cellular_component |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0072144 | Glomerular mesangial cell development | IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8517903613 | 0.0005133126 | 0.9999902473 | 0.0417003086 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.7517259767 |
| GSE13712_SHEAR | Up | 0.1728671209 |
| GSE13712_STATIC | Up | 0.4782890977 |
| GSE19018 | Down | -0.5790484064 |
| GSE19899_A1 | Down | -0.5512070752 |
| GSE19899_A2 | Down | -0.7450414729 |
| PubMed_21979375_A1 | Down | -2.3716084867 |
| PubMed_21979375_A2 | Down | -0.7235746216 |
| GSE35957 | Up | 0.1610995321 |
| GSE36640 | Up | 0.1275234929 |
| GSE54402 | Down | -1.0894816419 |
| GSE9593 | Down | -0.6605549650 |
| GSE43922 | Down | -1.0676493064 |
| GSE24585 | Up | 1.3936624627 |
| GSE37065 | Down | -0.8153961732 |
| GSE28863_A1 | Down | -0.2252151864 |
| GSE28863_A2 | Down | -1.3590748036 |
| GSE28863_A3 | Down | -0.5745528815 |
| GSE28863_A4 | Down | -0.0065654884 |
| GSE48662 | Down | -0.6694329960 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT041870 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | NA | hsa-miR-21 | 17991735 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
