HCSGD entry for RELB
1. General information
| Official gene symbol | RELB |
|---|---|
| Entrez ID | 5971 |
| Gene full name | v-rel reticuloendotheliosis viral oncogene homolog B |
| Other gene symbols | I-REL IREL REL-B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IEA | biological_process |
| GO:0019882 | Antigen processing and presentation | IEA | biological_process |
| GO:0043011 | Myeloid dendritic cell differentiation | IEA | biological_process |
| GO:0045063 | T-helper 1 cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0137242164 | 0.9146201588 | 0.2922614078 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3243663806 |
| GSE13712_SHEAR | Down | -0.0516457264 |
| GSE13712_STATIC | Up | 0.1593566314 |
| GSE19018 | Up | 0.0364269606 |
| GSE19899_A1 | Up | 0.4994453157 |
| GSE19899_A2 | Up | 1.3279361357 |
| PubMed_21979375_A1 | Up | 0.2539488602 |
| PubMed_21979375_A2 | Up | 1.3636079525 |
| GSE35957 | Down | -0.7022689652 |
| GSE36640 | Down | -0.2436127966 |
| GSE54402 | Up | 0.3754752173 |
| GSE9593 | Up | 0.5875721637 |
| GSE43922 | Up | 0.6639151535 |
| GSE24585 | Up | 0.0298442806 |
| GSE37065 | Up | 0.2235443246 |
| GSE28863_A1 | Up | 0.0491853525 |
| GSE28863_A2 | Up | 0.1956848539 |
| GSE28863_A3 | Down | -0.0578955548 |
| GSE28863_A4 | Down | -0.0816492520 |
| GSE48662 | Up | 0.0206242705 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029940 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25255445 | Here we demonstrate that in primary human fibroblasts, the alternative NF-kappaB pathway subunits NF-kappaB2 and RelB have multiple, but distinct, effects on the expression of key regulators of the cell cycle, reactive oxygen species (ROS) generation and protein stability |
| 25255445 | Specifically, following siRNA knockdown, quantitative PCR, western blot analyses and chromatin immunoprecipitation (ChIP) show that NF-kappaB2 regulates the expression of CDK4 and CDK6, while RelB, through the regulation of genes such as PSMA5 and ANAPC1, regulates the stability of p21WAF1 and the tumour suppressor p53 |
| 21552325 | Small hairpin RNA-mediated knockdown indicates that RelA induces this senescence program by acting upstream of the anaphase promoting complex and RelB to stabilize p27(KIP1) protein and p21(CIP1/WAF1) mRNA respectively |
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