HCSGD entry for RFX3

1. General information

Official gene symbolRFX3
Entrez ID5991
Gene full nameregulatory factor X, 3 (influences HLA class II expression)
Other gene symbolsbA32F11.1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDA IEAcellular_component
GO:0003677DNA bindingIEA TASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEA NASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IEAcellular_component
GO:0005667Transcription factor complexICcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEA ISSbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0031018Endocrine pancreas developmentISSbiological_process
GO:0042384Cilium assemblyIEA ISSbiological_process
GO:0044212Transcription regulatory region DNA bindingIDA IEAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0048469Cell maturationISSbiological_process
GO:0050796Regulation of insulin secretionIEA ISSbiological_process
GO:0060285Ciliary cell motilityIEA ISSbiological_process
GO:0060287Epithelial cilium movement involved in determination of left/right asymmetryIEA ISSbiological_process
GO:0072560Type B pancreatic cell maturationIEAbiological_process
GO:2000078Positive regulation of type B pancreatic cell developmentIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06535161280.29810992360.55095721601.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0242684058
GSE13712_SHEARUp0.3247472967
GSE13712_STATICUp0.1122337333
GSE19018Up0.3044573214
GSE19899_A1Up0.1807723357
GSE19899_A2Up0.1630963850
PubMed_21979375_A1Up1.1403241170
PubMed_21979375_A2Up0.4642299029
GSE35957Down-0.2704918945
GSE36640Down-0.5939934633
GSE54402Up0.7393830566
GSE9593Down-0.2905309530
GSE43922Up0.0244253065
GSE24585Up0.6418569617
GSE37065Up0.2091117049
GSE28863_A1Up0.5901827948
GSE28863_A2Down-0.9981060350
GSE28863_A3Down-0.5211803130
GSE28863_A4Down-0.4237872250
GSE48662Down-0.0220822081

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017663MicroarrayFunctional MTI (Weak)18185580
hsa-miR-148b-3pMIMAT0000759MIRT019371MicroarrayFunctional MTI (Weak)17612493
hsa-miR-128-3pMIMAT0000424MIRT021982MicroarrayFunctional MTI (Weak)17612493
hsa-miR-615-3pMIMAT0003283MIRT039992CLASHFunctional MTI (Weak)23622248
hsa-miR-342-3pMIMAT0000753MIRT043701CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.