HCSGD entry for RPS3
1. General information
| Official gene symbol | RPS3 |
|---|---|
| Entrez ID | 6188 |
| Gene full name | ribosomal protein S3 |
| Other gene symbols | S3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | biological_process |
| GO:0003684 | Damaged DNA binding | IDA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003729 | MRNA binding | IDA | molecular_function |
| GO:0003735 | Structural constituent of ribosome | IDA IEA NAS | molecular_function |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | IDA | molecular_function |
| GO:0004519 | Endonuclease activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IMP | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005840 | Ribosome | IEA | cellular_component |
| GO:0006412 | Translation | IC IEA NAS TAS | biological_process |
| GO:0006413 | Translational initiation | NAS TAS | biological_process |
| GO:0006414 | Translational elongation | TAS | biological_process |
| GO:0006415 | Translational termination | TAS | biological_process |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEP | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0015935 | Small ribosomal subunit | IEA | cellular_component |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0019058 | Viral life cycle | TAS | biological_process |
| GO:0019083 | Viral transcription | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0022627 | Cytosolic small ribosomal subunit | IDA | cellular_component |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IMP | biological_process |
| GO:0032587 | Ruffle membrane | IDA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045738 | Negative regulation of DNA repair | IMP | biological_process |
| GO:0051018 | Protein kinase A binding | IPI | molecular_function |
| GO:0051059 | NF-kappaB binding | IPI | molecular_function |
| GO:0051536 | Iron-sulfur cluster binding | NAS | molecular_function |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IMP | biological_process |
| GO:1900119 | Positive regulation of execution phase of apoptosis | IDA | biological_process |
| GO:1902546 | Positive regulation of DNA N-glycosylase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9897410205 | 0.0520170358 | 0.9999902473 | 0.4290670009 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0705912058 |
| GSE13712_SHEAR | Down | -0.3758197064 |
| GSE13712_STATIC | Down | -0.2366632549 |
| GSE19018 | Up | 0.3164363143 |
| GSE19899_A1 | Down | -0.1014056254 |
| GSE19899_A2 | Down | -0.3627461592 |
| PubMed_21979375_A1 | Down | -0.4040017672 |
| PubMed_21979375_A2 | Down | -0.4503614480 |
| GSE35957 | Down | -0.1480349942 |
| GSE36640 | Down | -0.4604363096 |
| GSE54402 | Up | 0.0971787524 |
| GSE9593 | Down | -0.1288922551 |
| GSE43922 | Down | -0.1862590303 |
| GSE24585 | Up | 0.0643043284 |
| GSE37065 | Down | -0.3963893776 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2859080219 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196b-3p | MIMAT0009201 | MIRT035761 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038586 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039732 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041288 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042817 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043461 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30e-3p | MIMAT0000693 | MIRT044122 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046540 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT047193 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047912 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051120 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
