HCSGD entry for ACSM3
1. General information
| Official gene symbol | ACSM3 |
|---|---|
| Entrez ID | 6296 |
| Gene full name | acyl-CoA synthetase medium-chain family member 3 |
| Other gene symbols | SA SAH |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0006633 | Fatty acid biosynthetic process | IEA | biological_process |
| GO:0008217 | Regulation of blood pressure | NAS | biological_process |
| GO:0015645 | Fatty acid ligase activity | IEA | molecular_function |
| GO:0042632 | Cholesterol homeostasis | NAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0047760 | Butyrate-CoA ligase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5302834847 | 0.4049749440 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0969579518 |
| GSE13712_SHEAR | Up | 0.1173347490 |
| GSE13712_STATIC | Down | -0.3037717821 |
| GSE19018 | Down | -0.0547954544 |
| GSE19899_A1 | Up | 0.1291880460 |
| GSE19899_A2 | Down | -0.0814102999 |
| PubMed_21979375_A1 | Down | -0.0013961214 |
| PubMed_21979375_A2 | Down | -0.0861183099 |
| GSE35957 | Down | -0.2527621494 |
| GSE36640 | Down | -0.1405366247 |
| GSE54402 | Down | -0.0419466472 |
| GSE9593 | Up | 0.1650660045 |
| GSE43922 | Up | 0.0105778179 |
| GSE24585 | Up | 0.3920517185 |
| GSE37065 | Up | 0.0241986639 |
| GSE28863_A1 | Down | -0.3433787501 |
| GSE28863_A2 | Down | -0.4892450377 |
| GSE28863_A3 | Up | 0.5597049912 |
| GSE28863_A4 | Up | 0.1840163534 |
| GSE48662 | Down | -0.0928865375 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15488656 | SAH is further hydrolyzed to adenosine and homocysteine by SAH-hydrolase |
| 15488656 | The formation of S-adenosylmethionine (SAM) is then demethylated to SAH |
| 15488656 | SAH, the metabolite of SAM, on the other hand is a powerful inhibitor of methyltransferase enzymes, competing for the SAM binding site |
| 15488656 | A concurrent decrease in SAM and an increase in SAH levels would inhibit methylation of many tissue components including proteins, DNA, RNA, phospholipids and other small molecules |
| 15488656 | SAM is the methyl donor of the reaction, and its demethylated product, SAH is the natural inhibitor of this reaction, as well as of most SAM-dependent methylations |
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