HCSGD entry for CCL7
1. General information
| Official gene symbol | CCL7 |
|---|---|
| Entrez ID | 6354 |
| Gene full name | chemokine (C-C motif) ligand 7 |
| Other gene symbols | FIC MARC MCP-3 MCP3 NC28 SCYA6 SCYA7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002548 | Monocyte chemotaxis | IC | biological_process |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006874 | Cellular calcium ion homeostasis | TAS | biological_process |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007010 | Cytoskeleton organization | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008009 | Chemokine activity | IDA | molecular_function |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0008360 | Regulation of cell shape | IDA | biological_process |
| GO:0010332 | Response to gamma radiation | IEA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IDA | biological_process |
| GO:0031726 | CCR1 chemokine receptor binding | IPI | molecular_function |
| GO:0031727 | CCR2 chemokine receptor binding | IEA | molecular_function |
| GO:0048245 | Eosinophil chemotaxis | IDA | biological_process |
| GO:0071361 | Cellular response to ethanol | IEA | biological_process |
| GO:2000503 | Positive regulation of natural killer cell chemotaxis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1246869040 | 0.0703151894 | 0.7206202195 | 0.5007484037 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5750438911 |
| GSE13712_SHEAR | Down | -0.2427241538 |
| GSE13712_STATIC | Down | -0.3980072711 |
| GSE19018 | Down | -1.0424331640 |
| GSE19899_A1 | Up | 0.0600539205 |
| GSE19899_A2 | Up | 0.4614993857 |
| PubMed_21979375_A1 | Down | -0.0120400224 |
| PubMed_21979375_A2 | Down | -0.7077414664 |
| GSE35957 | Down | -1.0714942957 |
| GSE36640 | Down | -0.0903731344 |
| GSE54402 | Down | -0.7877576194 |
| GSE9593 | Up | 0.9813655735 |
| GSE43922 | Up | 0.0144796337 |
| GSE24585 | Down | -0.0218904772 |
| GSE37065 | Up | 1.4137963196 |
| GSE28863_A1 | Down | -0.1688001100 |
| GSE28863_A2 | Up | 0.5497633513 |
| GSE28863_A3 | Up | 0.1225927836 |
| GSE28863_A4 | Up | 0.0661279530 |
| GSE48662 | Down | -0.2566932003 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029409 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 6207138 | Total glycosylated hemoglobin (GHb) was determined by affinity chromatography and the percentages of the minor Hbs FIa+b and FIc (of total Hb F) were determined by Bio-Rex 70 chromatography in whole blood samples and in red cell populations separated by Dextran 40 density gradient centrifugation |
| 6207138 | The absolute levels and the increase due to red cell aging of GHb, Hb FIa+b and Hb FIc were significantly reduced in the preterm samples compared to the term samples indicating decreased glycosylation in preterm fetus |
| 6207138 | When the nonglycosylated Hbs from term and preterm newborns were separated by Bio-Rex 70 chromatography after removal of the GHb by affinity chromatography, the acetylated form of Hb FIc also showed an increase with red cell aging indicating posttranslational enzymatic or nonenzymatic acetylation of Hb F during the entire life span of red cells |
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