HCSGD entry for CX3CL1

1. General information

Official gene symbolCX3CL1
Entrez ID6376
Gene full namechemokine (C-X3-C motif) ligand 1
Other gene symbolsABCD-3 C3Xkine CXC3 CXC3C NTN NTT SCYD1 fractalkine neurotactin
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005102Receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA IEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006935ChemotaxisIDAbiological_process
GO:0006952Defense responseTASbiological_process
GO:0006955Immune responseIEA TASbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0008009Chemokine activityIDA IEA TASmolecular_function
GO:0009986Cell surfaceIDA IEAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0019221Cytokine-mediated signaling pathwayIEA TASbiological_process
GO:0030593Neutrophil chemotaxisIEAbiological_process
GO:0030595Leukocyte chemotaxisTASbiological_process
GO:0032914Positive regulation of transforming growth factor beta1 productionIEAbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0048246Macrophage chemotaxisIEAbiological_process
GO:0048247Lymphocyte chemotaxisIEAbiological_process
GO:0050729Positive regulation of inflammatory responseIEPbiological_process
GO:0050902Leukocyte adhesive activationTASbiological_process
GO:0051041Positive regulation of calcium-independent cell-cell adhesionIDAbiological_process
GO:0060055Angiogenesis involved in wound healingIEAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29150649670.75316299910.99079836001.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0854547445
GSE13712_SHEARDown-0.1256503560
GSE13712_STATICDown-0.3336241852
GSE19018Up0.0018155327
GSE19899_A1Up0.0487453953
GSE19899_A2Up0.0775669556
PubMed_21979375_A1Down-0.1336378879
PubMed_21979375_A2Down-0.0652861647
GSE35957Up0.0067884473
GSE36640Down-0.0524615456
GSE54402Up0.0199694730
GSE9593Up0.5329591351
GSE43922Up0.0550909781
GSE24585Up0.1136366570
GSE37065Up0.0262432838
GSE28863_A1Down-0.0468862764
GSE28863_A2Up0.2967785725
GSE28863_A3Up0.4288830440
GSE28863_A4Up0.2210599012
GSE48662Up0.0436408708

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24185682Given senescent biliary epithelial cells (BECs) in damaged small bile ducts in primary biliary cirrhosis (PBC) show increased expression of chemokines CCL2 and CX3CL1 as SASP, we further examined an involvement of CCL2/CCR2 and CX3CL1/CX3CR1 systems in the pathogenesis of PBC
24185682METHODS: We examined immunohistochemically the expression of CCR2, CX3CR1, CCL2 and CX3CL1 in livers taken from the patients with PBC (n = 45) and control livers (n = 78), such as chronic viral hepatitis (CVH; n = 39)
24185682CONCLUSION: CCL2 and CX3CL1 produced by senescent BECs may promote infiltration of corresponding CCR2 and CX3CR1-expressing cells and further aggravate inflammation in bile duct lesion in PBC
20570384The expression of CCL2 and CX3CL1 was significantly higher in BECs in inflamed and damaged small bile ducts in PBC, when compared with non-inflamed bile ducts and control livers (p<0
20570384The expression of CCL2 and CX3CL1 was co-localized with the expression of senescent markers
20570384The expression of CCL2 and CX3CL1 was increased in senescent BECs in PBC
20212459We examined the effect of autophagy inhibitor (3-methyladenine) on the induction of cellular senescence and senescence-associated secretion (CCL2 and CX3CL1) in cultured murine BECs
20212459Furthermore, the secretion level of CCL2 and CX3CL1 increased significantly by various stress and suppressed by the inhibition of autophagy (P<0
16461801Such regulatory receptors include stimulatory and inhibitory members of the killer immunoglobulin-like receptor (KIR) family, the stimulatory c-type lectin receptor NKG2D, and CX3CR1, the receptor for the chemokine fractalkine
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