HCSGD entry for SHOX2

1. General information

Official gene symbolSHOX2
Entrez ID6474
Gene full nameshort stature homeobox 2
Other gene symbolsOG12 OG12X SHOT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0001501Skeletal system developmentTASbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0002063Chondrocyte developmentIEAbiological_process
GO:0003170Heart valve developmentIEAbiological_process
GO:0003209Cardiac atrium morphogenesisIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0007399Nervous system developmentTASbiological_process
GO:0007507Heart developmentTASbiological_process
GO:0032330Regulation of chondrocyte differentiationIEAbiological_process
GO:0035115Embryonic forelimb morphogenesisIEAbiological_process
GO:0045880Positive regulation of smoothened signaling pathwayIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0048743Positive regulation of skeletal muscle fiber developmentIEAbiological_process
GO:0050772Positive regulation of axonogenesisIEAbiological_process
GO:0060272Embryonic skeletal joint morphogenesisIEAbiological_process
GO:0060351Cartilage development involved in endochondral bone morphogenesisIEAbiological_process
GO:0060415Muscle tissue morphogenesisIEAbiological_process
GO:2000172Regulation of branching morphogenesis of a nerveIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16233811030.52433436040.79747733041.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1283798676
GSE13712_SHEARUp0.0172626991
GSE13712_STATICUp0.1501289932
GSE19018Up0.4295933682
GSE19899_A1Down-0.0568863007
GSE19899_A2Down-0.4964228904
PubMed_21979375_A1Down-0.3350788921
PubMed_21979375_A2Down-0.3638334223
GSE35957Up0.0483256706
GSE36640Up0.1180629554
GSE54402Up0.2555439113
GSE9593Up0.3111696657
GSE43922Down-0.1136263063
GSE24585Up0.5328915843
GSE37065Up0.2133698300
GSE28863_A1Down-0.0164427001
GSE28863_A2Down-0.0352987189
GSE28863_A3Up0.2325186998
GSE28863_A4Down-0.0791096984
GSE48662Up0.2443474972

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.