HCSGD entry for SLC1A3

1. General information

Official gene symbolSLC1A3
Entrez ID6507
Gene full namesolute carrier family 1 (glial high affinity glutamate transporter), member 3
Other gene symbolsEA6 EAAT1 GLAST GLAST1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001504Neurotransmitter uptakeTASbiological_process
GO:0003333Amino acid transmembrane transportIDAbiological_process
GO:0005313L-glutamate transmembrane transporter activityIDAmolecular_function
GO:0005314High-affinity glutamate transmembrane transporter activityIEAmolecular_function
GO:0005886Plasma membraneIEA TAScellular_component
GO:0006537Glutamate biosynthetic processIEAbiological_process
GO:0006811Ion transportTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0009416Response to light stimulusIEAbiological_process
GO:0009449Gamma-aminobutyric acid biosynthetic processIEAbiological_process
GO:0009611Response to woundingIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0016020MembraneIEA TAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016595Glutamate bindingIEAmolecular_function
GO:0017153Sodium:dicarboxylate symporter activityIEAmolecular_function
GO:0021545Cranial nerve developmentIEAbiological_process
GO:0031223Auditory behaviorIEAbiological_process
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042995Cell projectionIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043205FibrilIEAcellular_component
GO:0046677Response to antibioticIEAbiological_process
GO:0048667Cell morphogenesis involved in neuron differentiationIEAbiological_process
GO:0050806Positive regulation of synaptic transmissionIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0051938L-glutamate importIDA IEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0070779D-aspartate importIDAbiological_process
GO:1902475L-alpha-amino acid transmembrane transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04175128980.05959848790.45746253110.4597572685

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1321841163
GSE13712_SHEARDown-0.1535093258
GSE13712_STATICUp0.0552599330
GSE19018Up0.0670837688
GSE19899_A1Up0.0819782001
GSE19899_A2Up0.3656554721
PubMed_21979375_A1Up1.6751832885
PubMed_21979375_A2Down-0.0191208830
GSE35957Down-1.2461613890
GSE36640Down-0.2640657549
GSE54402Up1.0348600364
GSE9593Down-0.5625104655
GSE43922Up0.2886063037
GSE24585Down-1.7844944041
GSE37065Down-0.6181412483
GSE28863_A1Up1.1784617327
GSE28863_A2Up1.0244269235
GSE28863_A3Up0.0951319417
GSE28863_A4Down-0.1748323841
GSE48662Down-0.3416654698

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022261MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.