HCSGD entry for SLC12A1

1. General information

Official gene symbolSLC12A1
Entrez ID6557
Gene full namesolute carrier family 12 (sodium/potassium/chloride transporters), member 1
Other gene symbolsBSC1 NKCC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIEAbiological_process
GO:0005215Transporter activityIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006811Ion transportIEA TASbiological_process
GO:0006813Potassium ion transportIEAbiological_process
GO:0006814Sodium ion transportIEAbiological_process
GO:0006820Anion transportTASbiological_process
GO:0006821Chloride transportTASbiological_process
GO:0007588ExcretionIEAbiological_process
GO:0008511Sodium:potassium:chloride symporter activityTASmolecular_function
GO:0015377Cation:chloride symporter activityIEAmolecular_function
GO:0015698Inorganic anion transportTASbiological_process
GO:0016020MembraneIEA TAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0034220Ion transmembrane transportISSbiological_process
GO:0048878Chemical homeostasisIEAbiological_process
GO:0055085Transmembrane transportIEA TASbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53506202650.92620253030.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2788403143
GSE13712_SHEARDown-0.2232966770
GSE13712_STATICUp0.0323902328
GSE19018Up0.1674359655
GSE19899_A1Up0.1479214678
GSE19899_A2Up0.1414642531
PubMed_21979375_A1Up0.1720663963
PubMed_21979375_A2Up0.1552551731
GSE35957Up0.1742257726
GSE36640Down-0.0584072329
GSE54402Up0.1231542303
GSE9593Down-0.0096576373
GSE43922Up0.0130322228
GSE24585Down-0.0296519921
GSE37065Down-0.0084991810
GSE28863_A1Down-0.0460531437
GSE28863_A2Down-0.1155961816
GSE28863_A3Up0.1056465385
GSE28863_A4Up0.0523968040
GSE48662Down-0.0180898218

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TorasemideDB00214 APRD00295 | APRD00217
MethyclothiazideDB00232 APRD01104
ChlormerodrinDB00534 APRD00864
Potassium ChlorideDB00761 APRD01322
HydroflumethiazideDB00774 APRD01020
BumetanideDB00887 APRD00294
Etacrynic acidDB00903 APRD00251
TrichlormethiazideDB01021 APRD00031
QuinethazoneDB01325 -
PiretanideDB02925 EXPT03308

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.