HCSGD entry for BNIP3

1. General information

Official gene symbolBNIP3
Entrez ID664
Gene full nameBCL2/adenovirus E1B 19kDa interacting protein 3
Other gene symbolsNIP3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEA ISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA ISScellular_component
GO:0005635Nuclear envelopeIDAcellular_component
GO:0005654NucleoplasmIEA ISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005739MitochondrionIDA TAScellular_component
GO:0005740Mitochondrial envelopeIEAcellular_component
GO:0005741Mitochondrial outer membraneIDAcellular_component
GO:0006309Apoptotic DNA fragmentationIDAbiological_process
GO:0006338Chromatin remodelingIDAbiological_process
GO:0006915Apoptotic processIPIbiological_process
GO:0008219Cell deathIDA ISSbiological_process
GO:0008626Granzyme-mediated apoptotic signaling pathwayIDAbiological_process
GO:0010508Positive regulation of autophagyTASbiological_process
GO:0010637Negative regulation of mitochondrial fusionIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0030425DendriteIEA ISScellular_component
GO:0031307Integral component of mitochondrial outer membraneIDAcellular_component
GO:0031966Mitochondrial membraneIDA IMPcellular_component
GO:0035694Mitochondrial protein catabolic processIMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDA IEAmolecular_function
GO:0043065Positive regulation of apoptotic processIDA IEAbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043243Positive regulation of protein complex disassemblyIDAbiological_process
GO:0043653Mitochondrial fragmentation involved in apoptotic processIDAbiological_process
GO:0045837Negative regulation of membrane potentialIDAbiological_process
GO:0046902Regulation of mitochondrial membrane permeabilityIDAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048102Autophagic cell deathIEAbiological_process
GO:0050873Brown fat cell differentiationIEAbiological_process
GO:0051020GTPase bindingIPImolecular_function
GO:0051402Neuron apoptotic processIEA ISSbiological_process
GO:0051607Defense response to virusIDAbiological_process
GO:0055093Response to hyperoxiaIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0071279Cellular response to cobalt ionIMPbiological_process
GO:0071456Cellular response to hypoxiaIMPbiological_process
GO:0072593Reactive oxygen species metabolic processIDAbiological_process
GO:0090141Positive regulation of mitochondrial fissionIDAbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIDAbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayIEAbiological_process
GO:0097345Mitochondrial outer membrane permeabilizationIDAbiological_process
GO:1990144Intrinsic apoptotic signaling pathway in response to hypoxiaIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01966131610.18573627140.34129901900.8354038442

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8393349790
GSE13712_SHEARDown-0.1151887728
GSE13712_STATICUp0.1413520056
GSE19018Up3.2472132286
GSE19899_A1Up0.3228162668
GSE19899_A2Up0.5750234545
PubMed_21979375_A1Up1.1470341546
PubMed_21979375_A2Up0.0925275526
GSE35957Down-0.4369342020
GSE36640Down-1.5769890880
GSE54402Up0.5206452184
GSE9593Up0.0607018879
GSE43922Up0.1296002936
GSE24585Up0.0341989586
GSE37065Down-0.0776997863
GSE28863_A1Down-0.2017003601
GSE28863_A2Up0.4212037434
GSE28863_A3Down-0.4655155573
GSE28863_A4Down-0.1670355147
GSE48662Up0.1046274836

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT000305Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20332243
hsa-miR-221-3pMIMAT0000278MIRT004753Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20018759
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21193900The expression of c-Myc and cardiac death promoting gene Bnip3 were increased, and Pgc1-alpha and Ppar-alpha a decreased following T-H
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