HCSGD entry for SOX2

1. General information

Official gene symbolSOX2
Entrez ID6657
Gene full nameSRY (sex determining region Y)-box 2
Other gene symbolsANOP3 MCOPS3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001649Osteoblast differentiationIDAbiological_process
GO:0001654Eye developmentIEPbiological_process
GO:0001714Endodermal cell fate specificationIDAbiological_process
GO:0002052Positive regulation of neuroblast proliferationIEAbiological_process
GO:0003677DNA bindingIDA NASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDA NAScellular_component
GO:0005667Transcription factor complexTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006325Chromatin organizationNASbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDA NASbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0009611Response to woundingIEPbiological_process
GO:0010468Regulation of gene expressionIMPbiological_process
GO:0021781Glial cell fate commitmentNASbiological_process
GO:0021879Forebrain neuron differentiationIEAbiological_process
GO:0021983Pituitary gland developmentIEPbiological_process
GO:0021984Adenohypophysis developmentIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030539Male genitalia developmentIEAbiological_process
GO:0030858Positive regulation of epithelial cell differentiationIEAbiological_process
GO:0030900Forebrain developmentIEPbiological_process
GO:0030910Olfactory placode formationIEAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0035019Somatic stem cell maintenanceIDA IMPbiological_process
GO:0035198MiRNA bindingIDAmolecular_function
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043586Tongue developmentIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045665Negative regulation of neuron differentiationISSbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045668Negative regulation of osteoblast differentiationIEAbiological_process
GO:0045747Positive regulation of Notch signaling pathwayIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046148Pigment biosynthetic processIEAbiological_process
GO:0048286Lung alveolus developmentIEAbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0048839Inner ear developmentIEPbiological_process
GO:0048852Diencephalon morphogenesisIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIDAbiological_process
GO:0050910Detection of mechanical stimulus involved in sensory perception of soundIEAbiological_process
GO:0050973Detection of mechanical stimulus involved in equilibrioceptionIEAbiological_process
GO:0060042Retina morphogenesis in camera-type eyeIEAbiological_process
GO:0060235Lens induction in camera-type eyeIEAbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIEAbiological_process
GO:0070848Response to growth factorIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:0097150Neuronal stem cell maintenanceISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89377637630.42357210970.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0982020569
GSE13712_SHEARDown-0.0382596483
GSE13712_STATICDown-0.0658066624
GSE19018Up0.0328785620
GSE19899_A1Up0.0192694218
GSE19899_A2Up0.0196770837
PubMed_21979375_A1Up0.1069827050
PubMed_21979375_A2Down-0.0361016508
GSE35957Up0.0985471298
GSE36640Up0.0118873248
GSE54402Up0.0419179426
GSE9593Up0.0476643807
GSE43922Up0.0206241696
GSE24585Down-1.0026659851
GSE37065Up0.0506018400
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1139635710

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT000307FACS//Flow//GFP reporter assay//In situ hybridization//Luciferase reporter assay//qRT-PCR//Reporter assay;Western blot;qRT-PCR;OtherFunctional MTI19409607
hsa-miR-145-5pMIMAT0000437MIRT000307Luciferase reporter assayFunctional MTI23541921
hsa-miR-126-3pMIMAT0000445MIRT005370Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21304604
hsa-miR-522-3pMIMAT0002868MIRT005692Luciferase reporter assay//Western blotNon-Functional MTI21304604
hsa-miR-34c-5pMIMAT0000686MIRT006227Luciferase reporter assay//Western blotFunctional MTI22020437
hsa-miR-34a-5pMIMAT0000255MIRT006223Luciferase reporter assay//Western blotFunctional MTI22020437
hsa-miR-34b-3pMIMAT0004676MIRT006226Luciferase reporter assay//Western blotFunctional MTI22020437
hsa-miR-140-5pMIMAT0000431MIRT007030Luciferase reporter assayFunctional MTI23060440
hsa-miR-429MIMAT0001536MIRT007184Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23111103
hsa-miR-128-3pMIMAT0000424MIRT021924Reporter assayNon-Functional MTI19409607
hsa-miR-122-5pMIMAT0000421MIRT023259MicroarrayFunctional MTI (Weak)17612493
hsa-miR-21-5pMIMAT0000076MIRT030694MicroarrayFunctional MTI (Weak)18591254
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 24 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27336873The expressions of lens progenitor cell-related markers Sox2, Abcg2, and Ki67 were first examined in human lens epithelial cells (HLECs) in situ
27336873Ki67, Sox2, and Abcg2 HLECs in lens capsules were clearly more abundant in young people than in patients older than 50 years, and they were almost absent in patients older than 60 years
27297181Notably, Tert expression increased colony formation of induced pluripotent stem (iPS) cells after the introduction of four reprogramming factors, Oct-4, klf4, SOX-2, and c-Myc into the transgenic fibroblasts
26896279Once formed, tumor organoids grew for months and displayed regional heterogeneity with a rapidly dividing outer region of SOX2(+), OLIG2(+), and TLX(+) cells surrounding a hypoxic core of primarily non-stem senescent cells and diffuse, quiescent CSCs
26878385BACKGROUND: SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs)
26878385METHODS: SOX2 and SOX9 levels were examined in human biopsies
26878385Gain and loss of function determined the impact of altering SOX2 and SOX9 on cell proliferation, senescence, stem cell activity, tumorigenesis and chemoresistance
26878385RESULTS: SOX2 and SOX9 expression correlates positively in glioma cells and glioblastoma biopsies
26878385Mechanistic investigations revealed that SOX2 acts upstream of SOX9
26878385We identify that rapamycin abrogate SOX protein expression and provide evidence that a combination of rapamycin and temozolomide inhibits tumor growth in cells with high SOX2/SOX9
26860864In addition, polyploid cells were positive for markers of embryonic stemness (OCT4, SOX2, NANOG) and senescence (p16INK4a)
26514209Syndecan-1 expression diminished, whereas stem cell markers such as SOX2, NANOG, OCT4, and E2F3 increased
26102294SOX2 and NANOG expression did not change following ETO treatment suggesting a dissociation of OCT4A from its pluripotency function
26096152Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSC) by the forced expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC
26089914For each early passage BM-MSC sample (5th or 6th passages), the normalized protein expression levels of senescence-associated markers p16(INK4A), p21(WAF1), SOD2, and rpS6(S240/244); the concentration of IL6 and IL8 in cell culture supernatants; and the normalized gene expression levels of pluripotency markers OCT4, NANOG, and SOX2 were correlated with final population doubling (PD) number
25515777The acquisition of pluripotent cells can be achieved by combined overexpression of transcription factors Oct4, Klf4, Sox2 and c-Myc in somatic cells
25279549The BORIS-positive cells isolated using BORIS-molecular beacon, expressed higher telomerase hTERT, stem cell (NANOG, OCT4, SOX2) and cancer stem cell marker genes (CD44 and ALDH1) compared to the BORIS-negative tumor cells
24979747Further investigation showed that ginsenoside Rg1 protected NSCs/NPCs (neural stem cells/progenitor cells) shown by increased level of SOX-2 expression; reduced astrocytes activation shown by decrease level of Aeg-1 expression; increased the hippocampal cell proliferation; enhanced the activity of the antioxidant enzymes GSH-Px (glutathione peroxidase) and SOD (Superoxide Dismutase); decreased the levels of IL-1beta, IL-6 and TNF-alpha, which are the proinflammatory cytokines; increased the telomere lengths and telomerase activity; and down-regulated the mRNA expression of cellular senescence associated genes p53, p21Cip1/Waf1 and p19Arf in the hippocampus of aged rats
24763337Introduction of "reprogramming factors", Oct4, Sox2, Klf4, cMyc and Lin28, into senescent fibroblasts and measuring the changes in HP1beta mobility as reprogramming proceeds shows that the mobility of HP1beta in senescent cells increases and by day 9 is the same as that found in young fibroblasts
24156782AT13387 effectively reduced both the number and size of C666-1 tumor spheres with decreased expression of NPC CSC-like markers CD44 and SOX2
23763475H2 O2 upregulated the expression of osteoblast- and adipocyte-associated genes in iPSC during their differentiation; however, short-term H2 O2 -induced oxidative stress did not affect the protein expression of the pluripotency markers, octamer-binding transcription factor 4 and sex-determining region Y-box 2
23451179Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells
23451179Here, we found that Sox2, a key transcription factor in the regulation of the "stemness" of embryonic stem cells and induced-pluripotent stem cells, strongly induced autophagic phenomena, including intracellular vacuole formation and lysosomal activation in colon cancer cells
23451179Taken together, our results demonstrated that regulation of autophagy mediated by Sox2 is a mechanism-driven novel strategy to treat human colon cancers
23318426Here we demonstrate that the introduction of defined reprogramming factors (OCT4, SOX2, Klf4 and c-Myc) into MCF-10A nontumorigenic mammary epithelial cells, followed by partial differentiation, transforms the bulk of cells into tumorigenic CD44(+)/CD24(low) cells with CSC properties, termed here as induced CSC-like-10A or iCSCL-10A cells
22683798Two hiPSC lines, hiPSC (1) and hiPSC (2) were generated from human dermal fibroblasts using OCT-4, SOX-2, KLF-4, c-Myc via retroviral-based reprogramming
21694780Meanwhile, the expression of genes associated with stem cell self-renewal such as Oct4 and Sox2 declined markedly
21636552Onset of senescence was associated with decreased expression of neural stem cell markers including SOX2
21562774They showed alkaline phosphatase activity and expressed ESC markers, as shown by immunostaining of OCT4, SOX2, SSEA4, and TRA-1-81 as well as reverse-transcription polymerase chain reaction (RT-PCR) for OCT4 and NANOG transcripts
20457152Here, we studied the role of the pluripotency and self-renewal stem cell genes NANOG, OCT4 and SOX2 in this polyploidy-dependent survival mechanism
20457152IF analysis also showed that the ETC generate PML bodies that appear to concentrate OCT4, NANOG and SOX2 proteins, which extend into complex nuclear networks
20457152These polyploid tumour cells resist apoptosis, overcome cellular senescence and undergo bi- and multi-polar divisions transmitting the up-regulated OCT4, NANOG and SOX2 self-renewal cassette to their descendents
18668528Recently, isolation of patient-specific induced pluripotent stem (iPS) cells was achieved by transducing fibroblasts with four transcription factors, Oct4, Sox2, Klf4, and c-Myc
18358537An OBGF400 neuronal phenotype was indicated by the recognition of a transfected neuronal progenitor-cell-specific tubulin-alpha1 gene promoter, intracellular presence of early neuronal markers (TuJ1, neuregulin-1, doublecortin and SOX2) and enhanced expression of neuronal- and progenitor lineage-active genes (MAP2, nestin, ENO and Syn1) compared to that of porcine epithelial cells
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