HCSGD entry for SPI1

1. General information

Official gene symbolSPI1
Entrez ID6688
Gene full namespleen focus forming virus (SFFV) proviral integration oncogene spi1
Other gene symbolsOF PU.1 SFPI1 SPI-1 SPI-A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingISSmolecular_function
GO:0001047Core promoter bindingIDAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingISSmolecular_function
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0002320Lymphoid progenitor cell differentiationIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0030098Lymphocyte differentiationIEAbiological_process
GO:0030218Erythrocyte differentiationIEAbiological_process
GO:0030225Macrophage differentiationIEAbiological_process
GO:0030851Granulocyte differentiationIEAbiological_process
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0043011Myeloid dendritic cell differentiationIEAbiological_process
GO:0043966Histone H3 acetylationIMPbiological_process
GO:0044027Hypermethylation of CpG islandIDAbiological_process
GO:0045347Negative regulation of MHC class II biosynthetic processIEAbiological_process
GO:0045646Regulation of erythrocyte differentiationIMPbiological_process
GO:0045814Negative regulation of gene expression, epigeneticIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0051525NFAT protein bindingISSmolecular_function
GO:0060033Anatomical structure regressionIEAbiological_process
GO:0090241Negative regulation of histone H4 acetylationIMPbiological_process
GO:1902262Apoptotic process involved in patterning of blood vesselsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68268671400.76736451880.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0083311411
GSE13712_SHEARDown-0.0046248988
GSE13712_STATICDown-0.0116780006
GSE19018Up0.1814534010
GSE19899_A1Up0.0583556574
GSE19899_A2Up0.1322764763
PubMed_21979375_A1Down-0.2188450366
PubMed_21979375_A2Up0.0413545578
GSE35957Up0.1187143660
GSE36640Down-0.0871147064
GSE54402Down-0.0004383835
GSE9593Down-0.0269971655
GSE43922Up0.0506707119
GSE24585Up0.0783245083
GSE37065Down-0.0588549481
GSE28863_A1Down-0.2010555357
GSE28863_A2Down-0.1703002886
GSE28863_A3Up0.2828609422
GSE28863_A4Up0.0182192039
GSE48662Up0.2584154533

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT004282Luciferase reporter assayFunctional MTI19386588
hsa-miR-155-5pMIMAT0000646MIRT004282Reporter assayFunctional MTI20680360
hsa-miR-155-5pMIMAT0000646MIRT004282ProteomicsFunctional MTI (Weak)18668040
hsa-miR-569MIMAT0003234MIRT004827Luciferase reporter assayFunctional MTI21162035
hsa-miR-34a-5pMIMAT0000255MIRT005724Luciferase reporter assay//Reporter assayNon-Functional MTI20598588
hsa-miR-424-5pMIMAT0001341MIRT005928ChIP-seq//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20972335
hsa-miR-9-5pMIMAT0000441MIRT021410MicroarrayFunctional MTI (Weak)17612493
hsa-miR-296-3pMIMAT0004679MIRT038360CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT00006461hsa-miR-155{Western blot}{endogenous}19386588
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25540416EBNA3A was at MYC, CDKN2A/B, CCND2, CXCL9/10, and BCL2, together with RUNX3, BATF, IRF4, and SPI1
195130631-endocing Sfpi1 gene consists mostly of C:G to T:A transitions at a CpG site and is likely to be of spontaneous origin
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