HCSGD entry for SPTB
1. General information
| Official gene symbol | SPTB |
|---|---|
| Entrez ID | 6710 |
| Gene full name | spectrin, beta, erythrocytic |
| Other gene symbols | EL3 HS2 HSPTB1 SPH2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | TAS | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006779 | Porphyrin-containing compound biosynthetic process | IEA | biological_process |
| GO:0007009 | Plasma membrane organization | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008091 | Spectrin | IEA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0014731 | Spectrin-associated cytoskeleton | IDA | cellular_component |
| GO:0015629 | Actin cytoskeleton | TAS | cellular_component |
| GO:0030097 | Hemopoiesis | IEA | biological_process |
| GO:0030506 | Ankyrin binding | IPI | molecular_function |
| GO:0031235 | Intrinsic component of the cytoplasmic side of the plasma membrane | TAS | cellular_component |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0051015 | Actin filament binding | IDA | molecular_function |
| GO:0051693 | Actin filament capping | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7957849512 | 0.7688072490 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0712012990 |
| GSE13712_SHEAR | Up | 0.0228522758 |
| GSE13712_STATIC | Up | 0.0992020467 |
| GSE19018 | Up | 0.0542894502 |
| GSE19899_A1 | Up | 0.0305638028 |
| GSE19899_A2 | Up | 0.1727492743 |
| PubMed_21979375_A1 | Down | -0.1579687640 |
| PubMed_21979375_A2 | Up | 0.0659623178 |
| GSE35957 | Up | 0.1935952178 |
| GSE36640 | Up | 0.0099953245 |
| GSE54402 | Down | -0.1191080884 |
| GSE9593 | Down | -0.0489854363 |
| GSE43922 | Up | 0.0212561550 |
| GSE24585 | Up | 0.0893735323 |
| GSE37065 | Down | -0.0424355410 |
| GSE28863_A1 | Down | -0.0969448622 |
| GSE28863_A2 | Down | -0.1969448337 |
| GSE28863_A3 | Up | 0.1435464186 |
| GSE28863_A4 | Down | -0.0195475863 |
| GSE48662 | Up | 0.3663138636 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018509 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043541 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10215895 | As spectrin ubiquitination occurs on domains alphaIII and alphaV of alpha-spectrin, and domain alphaV contains the nucleation site for the association of the alpha- and beta-spectrin chains, alterations in ubiquitination during red cell ageing could affect the stability and deformability of the erythrocyte membrane |
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