HCSGD entry for SPTBN1
1. General information
| Official gene symbol | SPTBN1 |
|---|---|
| Entrez ID | 6711 |
| Gene full name | spectrin, beta, non-erythrocytic 1 |
| Other gene symbols | ELF SPTB2 betaSpII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000281 | Mitotic cytokinesis | IMP | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005543 | Phospholipid binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007009 | Plasma membrane organization | IMP | biological_process |
| GO:0007182 | Common-partner SMAD protein phosphorylation | IEA | biological_process |
| GO:0007184 | SMAD protein import into nucleus | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008091 | Spectrin | IEA | cellular_component |
| GO:0014731 | Spectrin-associated cytoskeleton | NAS | cellular_component |
| GO:0030506 | Ankyrin binding | IPI NAS | molecular_function |
| GO:0030673 | Axolemma | IEA ISS | cellular_component |
| GO:0031430 | M band | IEA | cellular_component |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0032437 | Cuticular plate | IEA | cellular_component |
| GO:0043001 | Golgi to plasma membrane protein transport | IMP | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0051693 | Actin filament capping | IEA | biological_process |
| GO:0071709 | Membrane assembly | IMP | biological_process |
| GO:0072661 | Protein targeting to plasma membrane | IEA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8544876372 | 0.3011488469 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1456187769 |
| GSE13712_SHEAR | Down | -0.1535297087 |
| GSE13712_STATIC | Down | -0.2711686617 |
| GSE19018 | Up | 0.1778471030 |
| GSE19899_A1 | Down | -0.0314699694 |
| GSE19899_A2 | Down | -0.1107810529 |
| PubMed_21979375_A1 | Down | -0.1997033542 |
| PubMed_21979375_A2 | Down | -0.1313222937 |
| GSE35957 | Up | 0.1323169313 |
| GSE36640 | Up | 0.1768739615 |
| GSE54402 | Down | -0.1191220310 |
| GSE9593 | Up | 0.5774955934 |
| GSE43922 | Down | -0.0204838604 |
| GSE24585 | Down | -0.4848575617 |
| GSE37065 | Down | -0.0450550354 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0270105275 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021336 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024854 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025300 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026166 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT027962 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035983 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040242 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-589-3p | MIMAT0003256 | MIRT040504 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041403 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042558 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043543 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT044864 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050120 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051442 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052584 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
