HCSGD entry for ZFP36L2
1. General information
| Official gene symbol | ZFP36L2 |
|---|---|
| Entrez ID | 678 |
| Gene full name | ZFP36 ring finger protein-like 2 |
| Other gene symbols | BRF2 ERF-2 ERF2 RNF162C TIS11D |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0006402 | MRNA catabolic process | ISS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0017091 | AU-rich element binding | IDA | molecular_function |
| GO:0030097 | Hemopoiesis | ISS | biological_process |
| GO:0033077 | T cell differentiation in thymus | IEA | biological_process |
| GO:0035019 | Somatic stem cell maintenance | ISS | biological_process |
| GO:0035925 | MRNA 3'-UTR AU-rich region binding | IEA | molecular_function |
| GO:0043488 | Regulation of mRNA stability | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048103 | Somatic stem cell division | ISS | biological_process |
| GO:0060216 | Definitive hemopoiesis | ISS | biological_process |
| GO:1900153 | Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | ISS | biological_process |
| GO:2000737 | Negative regulation of stem cell differentiation | ISS | biological_process |
| GO:2001141 | Regulation of RNA biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5054257475 | 0.0257535086 | 0.9999902473 | 0.3082574352 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0296208987 |
| GSE13712_SHEAR | Down | -0.0516877196 |
| GSE13712_STATIC | Down | -0.2520030396 |
| GSE19018 | Up | 0.0755782683 |
| GSE19899_A1 | Down | -0.7602285214 |
| GSE19899_A2 | Down | -0.5488166197 |
| PubMed_21979375_A1 | Down | -0.8080747844 |
| PubMed_21979375_A2 | Down | -0.6896166402 |
| GSE35957 | Down | -0.0200709598 |
| GSE36640 | Down | -0.4033048098 |
| GSE54402 | Down | -0.5634811054 |
| GSE9593 | Up | 0.3142966736 |
| GSE43922 | Down | -0.7270211659 |
| GSE24585 | Down | -0.3522827386 |
| GSE37065 | Up | 0.0948024586 |
| GSE28863_A1 | Up | 0.4883602235 |
| GSE28863_A2 | Up | 0.6123276239 |
| GSE28863_A3 | Up | 0.3604909731 |
| GSE28863_A4 | Down | -0.1949425705 |
| GSE48662 | Up | 0.2944501474 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002907 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-421 | MIMAT0003339 | MIRT016129 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-375 | MIMAT0000728 | MIRT019787 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039272 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045099 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047326 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050676 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
