HCSGD entry for STIM1
1. General information
| Official gene symbol | STIM1 |
|---|---|
| Entrez ID | 6786 |
| Gene full name | stromal interaction molecule 1 |
| Other gene symbols | D11S4896E GOK TAM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002115 | Store-operated calcium entry | IEA | biological_process |
| GO:0005246 | Calcium channel regulator activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IDA | molecular_function |
| GO:0005513 | Detection of calcium ion | IDA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0015279 | Store-operated calcium channel activity | IEA | molecular_function |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0030426 | Growth cone | IEA | cellular_component |
| GO:0032237 | Activation of store-operated calcium channel activity | IDA | biological_process |
| GO:0032541 | Cortical endoplasmic reticulum | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0051010 | Microtubule plus-end binding | IDA | molecular_function |
| GO:0051924 | Regulation of calcium ion transport | IDA | biological_process |
| GO:2001256 | Regulation of store-operated calcium entry | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4166626154 | 0.8667952699 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0182455805 |
| GSE13712_SHEAR | Up | 0.0653515832 |
| GSE13712_STATIC | Down | -0.0669292954 |
| GSE19018 | Up | 0.0975487491 |
| GSE19899_A1 | Up | 0.0192898682 |
| GSE19899_A2 | Down | -0.0026077981 |
| PubMed_21979375_A1 | Up | 0.1478955280 |
| PubMed_21979375_A2 | Up | 0.0699050799 |
| GSE35957 | Up | 0.0749281108 |
| GSE36640 | Up | 0.3972714192 |
| GSE54402 | Down | -0.0607501793 |
| GSE9593 | Up | 0.0338094155 |
| GSE43922 | Up | 0.0377500704 |
| GSE24585 | Down | -0.0020514523 |
| GSE37065 | Down | -0.2461264909 |
| GSE28863_A1 | Up | 0.0076489744 |
| GSE28863_A2 | Up | 0.3445578021 |
| GSE28863_A3 | Down | -0.0032047963 |
| GSE28863_A4 | Up | 0.0349475722 |
| GSE48662 | Up | 0.5011963470 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020653 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032252 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039069 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050790 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26257076 | The importance of store-operated Ca(2+) entry (SOCE) and the role of its key molecular regulators, STIM1 and ORAI1, in the development of cancer are emerging |
| 26257076 | Here, we report an unexpected dual function of SOCE in prostate cancer progression by revealing a decrease in the expression of STIM1 in human hyperplasia and tumor tissues of high histological grade and by demonstrating that STIM1 and ORAI1 inhibit cell growth by arresting the G0/G1 phase and enhancing cell senescence in human prostate cancer cells |
| 26257076 | In addition, STIM1 and ORAI1 inhibited NF-kappaB signaling and remodeled the tumor microenvironment by reducing the formation of M2 phenotype macrophages, possibly creating an unfavorable tumor microenvironment and inhibiting cancer development |
| 26257076 | However, STIM1 also promoted cell migration and the epithelial-to-mesenchymal transition by activating TGF-beta, Snail and Wnt/beta-Catenin pathways |
| 26257076 | Thus, our study revealed novel regulatory effects and the mechanisms by which STIM1 affects cell senescence, tumor migration and the tumor microenvironment, revealing that STIM1 has multiple functions in prostate cancer cells |
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