HCSGD entry for STK4

1. General information

Official gene symbolSTK4
Entrez ID6789
Gene full nameserine/threonine kinase 4
Other gene symbolsKRS2 MST1 TIIAC YSK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0000902Cell morphogenesisIDAbiological_process
GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001841Neural tube formationIEAbiological_process
GO:0003157Endocardium developmentIEAbiological_process
GO:0004674Protein serine/threonine kinase activityEXP IDA IEAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIBAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006915Apoptotic processIDAbiological_process
GO:0007165Signal transductionIEA TASbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0023014Signal transduction by phosphorylationIBAbiological_process
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0035329Hippo signalingIDA TASbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0042325Regulation of phosphorylationTASbiological_process
GO:0042327Positive regulation of phosphorylationTASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043085Positive regulation of catalytic activityTASbiological_process
GO:0043539Protein serine/threonine kinase activator activityTASmolecular_function
GO:0045859Regulation of protein kinase activityTASbiological_process
GO:0045860Positive regulation of protein kinase activityTASbiological_process
GO:0046621Negative regulation of organ growthIEAbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0046983Protein dimerization activityIDAmolecular_function
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0060215Primitive hemopoiesisIEAbiological_process
GO:0060706Cell differentiation involved in embryonic placenta developmentIEAbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityTASbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:0097284Hepatocyte apoptotic processIEAbiological_process
GO:1902043Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01200253790.99053206190.27390979201.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1472703335
GSE13712_SHEARUp0.3504152787
GSE13712_STATICUp0.0454671145
GSE19018Down-0.0888235857
GSE19899_A1Up0.5281915505
GSE19899_A2Up0.6460173436
PubMed_21979375_A1Up1.0649568792
PubMed_21979375_A2Up1.0980602021
GSE35957Down-0.0596876461
GSE36640Down-0.1424200774
GSE54402Up0.6426895913
GSE9593Up0.0782948298
GSE43922Up0.8713325246
GSE24585Up0.1721679831
GSE37065Up0.1574210223
GSE28863_A1Up0.1810278978
GSE28863_A2Up0.3684990245
GSE28863_A3Down-0.3244759446
GSE28863_A4Up0.0353511582
GSE48662Up0.2553112276

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-373-3pMIMAT0000726MIRT002541Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-92a-3pMIMAT0000092MIRT048938CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-373-3pMIMAT0000726NAhsa-miR-37315685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.