HCSGD entry for TBP

1. General information

Official gene symbolTBP
Entrez ID6908
Gene full nameTATA box binding protein
Other gene symbolsGTF2D GTF2D1 HDL4 SCA17 TFIID
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001103RNA polymerase II repressing transcription factor bindingIEAmolecular_function
GO:0001939Female pronucleusIEAcellular_component
GO:0001940Male pronucleusIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005669Transcription factor TFIID complexIDA IEAcellular_component
GO:0005672Transcription factor TFIIA complexIDAcellular_component
GO:0005719Nuclear euchromatinIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006352DNA-templated transcription, initiationIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIC IDA IEA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterIC TASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:0006383Transcription from RNA polymerase III promoterIDA IEA TASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008219Cell deathIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0070491Repressing transcription factor bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49397235670.42627261120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0368157946
GSE13712_SHEARUp0.0539175045
GSE13712_STATICDown-0.0489308935
GSE19018Down-0.3940776304
GSE19899_A1Down-0.1240629547
GSE19899_A2Up0.0554460104
PubMed_21979375_A1Up0.4121827726
PubMed_21979375_A2Down-0.0215394128
GSE35957Down-0.1332382370
GSE36640Down-0.6853398551
GSE54402Up0.2249271524
GSE9593Down-0.0293300422
GSE43922Up0.0519083342
GSE24585Up0.0023932668
GSE37065Up0.1911973745
GSE28863_A1Up0.2067624059
GSE28863_A2Up0.4895531881
GSE28863_A3Up0.1573291080
GSE28863_A4Down-0.2251825113
GSE48662Down-0.4187623977

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT040014CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051286CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-146a-5pMIMAT00004491hsa-miR-146a{Western blot}{overexpression by miRNA precursor transfection}20451497
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

8174635Two activities were more abundant in senescent cells: OctBP and one TFIID complex
8174635This TFIID complex was present in quiescent cells, but absent from four human cell lines that lack a functional retinoblastoma protein (pRb); both pRb-specific and TFIID-specific antibodies selectively disrupted it
8174635The data suggest that an altered profile of transcription factors may specify the senescent phenotype and that pRb may interact with TFIID or a TFIID-associated protein(s)
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