HCSGD entry for TCF12
1. General information
| Official gene symbol | TCF12 |
|---|---|
| Entrez ID | 6938 |
| Gene full name | transcription factor 12 |
| Other gene symbols | HEB HTF4 HsT17266 bHLHb20 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007517 | Muscle organ development | TAS | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045666 | Positive regulation of neuron differentiation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
| GO:0070888 | E-box binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9911216177 | 0.0085958360 | 0.9999902473 | 0.1849068627 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2126470868 |
| GSE13712_SHEAR | Down | -0.0542384770 |
| GSE13712_STATIC | Down | -0.1438707904 |
| GSE19018 | Down | -0.4943637304 |
| GSE19899_A1 | Down | -0.2580854309 |
| GSE19899_A2 | Down | -0.8038063398 |
| PubMed_21979375_A1 | Down | -0.4036035659 |
| PubMed_21979375_A2 | Down | -0.8976473990 |
| GSE35957 | Down | -0.0797929669 |
| GSE36640 | Down | -0.7119084271 |
| GSE54402 | Down | -0.3383969135 |
| GSE9593 | Down | -0.3948758141 |
| GSE43922 | Down | -0.3729710731 |
| GSE24585 | Up | 0.4118156141 |
| GSE37065 | Down | -0.0535744501 |
| GSE28863_A1 | Up | 0.1692796662 |
| GSE28863_A2 | Down | -0.3134663844 |
| GSE28863_A3 | Down | -0.4575856685 |
| GSE28863_A4 | Up | 0.0646674781 |
| GSE48662 | Down | -0.8700896519 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-211-5p | MIMAT0000268 | MIRT006464 | Immunofluorescence//Microarray//qRT-PCR//Western blot | Functional MTI | 22523078 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005845 | Luciferase reporter assay//Microarray//qRT-PCR | Functional MTI | 21282569 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005845 | Immunofluorescence//Microarray//qRT-PCR//Western blot | Functional MTI | 22523078 |
| hsa-miR-375 | MIMAT0000728 | MIRT019970 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020994 | Reporter assay;Other | Non-Functional MTI | 20584899 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030001 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1224-3p | MIMAT0005459 | MIRT036549 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
