HCSGD entry for TCOF1
1. General information
| Official gene symbol | TCOF1 |
|---|---|
| Entrez ID | 6949 |
| Gene full name | Treacher Collins-Franceschetti syndrome 1 |
| Other gene symbols | MFD1 TCS1 treacle |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0005215 | Transporter activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0042790 | Transcription of nuclear large rRNA transcript from RNA polymerase I promoter | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7109507162 | 0.2257909882 | 0.9999902473 | 0.9140333128 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0804366948 |
| GSE13712_SHEAR | Up | 0.0918281805 |
| GSE13712_STATIC | Down | -0.1186963610 |
| GSE19018 | Up | 0.0570791575 |
| GSE19899_A1 | Up | 0.0363678242 |
| GSE19899_A2 | Up | 0.0768681167 |
| PubMed_21979375_A1 | Up | 0.0364548089 |
| PubMed_21979375_A2 | Down | -0.0886297346 |
| GSE35957 | Down | -0.3717282563 |
| GSE36640 | Down | -0.9000454578 |
| GSE54402 | Up | 0.0324264294 |
| GSE9593 | Down | -0.3572534962 |
| GSE43922 | Up | 0.1857751899 |
| GSE24585 | Down | -0.6027961069 |
| GSE37065 | Down | -0.2021531744 |
| GSE28863_A1 | Down | -0.0264934839 |
| GSE28863_A2 | Up | 0.1295742704 |
| GSE28863_A3 | Up | 0.4302604135 |
| GSE28863_A4 | Up | 0.1165756771 |
| GSE48662 | Up | 0.0036192370 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022519 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025404 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025762 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032257 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037490 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038780 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040239 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040570 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043143 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT043611 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046740 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048102 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049104 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
