HCSGD entry for TDG
1. General information
| Official gene symbol | TDG |
|---|---|
| Entrez ID | 6996 |
| Gene full name | thymine-DNA glycosylase |
| Other gene symbols | hTDG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001104 | RNA polymerase II transcription cofactor activity | IEA | molecular_function |
| GO:0003684 | Damaged DNA binding | TAS | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IDA | molecular_function |
| GO:0005080 | Protein kinase C binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | IEA TAS | biological_process |
| GO:0006284 | Base-excision repair | IDA TAS | biological_process |
| GO:0006285 | Base-excision repair, AP site formation | TAS | biological_process |
| GO:0006298 | Mismatch repair | IDA IEA | biological_process |
| GO:0008263 | Pyrimidine-specific mismatch base pair DNA N-glycosylase activity | IDA | molecular_function |
| GO:0009790 | Embryo development | IEA ISS | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0016799 | Hydrolase activity, hydrolyzing N-glycosyl compounds | IEA | molecular_function |
| GO:0019104 | DNA N-glycosylase activity | IDA IEA | molecular_function |
| GO:0030983 | Mismatched DNA binding | IDA IEA | molecular_function |
| GO:0032091 | Negative regulation of protein binding | IEA | biological_process |
| GO:0032183 | SUMO binding | IEA | molecular_function |
| GO:0035562 | Negative regulation of chromatin binding | IEA | biological_process |
| GO:0040029 | Regulation of gene expression, epigenetic | ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043566 | Structure-specific DNA binding | IEA ISS | molecular_function |
| GO:0045008 | Depyrimidination | TAS | biological_process |
| GO:0080111 | DNA demethylation | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4428476464 | 0.1516390525 | 0.9999902473 | 0.7522598192 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1995413239 |
| GSE13712_SHEAR | Down | -0.0159690569 |
| GSE13712_STATIC | Up | 0.1365867405 |
| GSE19018 | Down | -0.3262366249 |
| GSE19899_A1 | Up | 0.2836442955 |
| GSE19899_A2 | Up | 0.1919987200 |
| PubMed_21979375_A1 | Up | 1.0689578143 |
| PubMed_21979375_A2 | Up | 0.4684514735 |
| GSE35957 | Up | 0.1589851929 |
| GSE36640 | Down | -0.2871856046 |
| GSE54402 | Up | 0.1159018911 |
| GSE9593 | Down | -0.5395500863 |
| GSE43922 | Up | 0.5470548730 |
| GSE24585 | Down | -0.2758354184 |
| GSE37065 | Down | -0.1329442815 |
| GSE28863_A1 | Down | -0.3206954977 |
| GSE28863_A2 | Down | -0.2496563689 |
| GSE28863_A3 | Down | -0.1891889880 |
| GSE28863_A4 | Down | -0.0503696337 |
| GSE48662 | Down | -0.3465878420 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | MIRT001921 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 18390668 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024737 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026661 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045731 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046007 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | NA | hsa-miR-29c | 18390668 | |||
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 21935352 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
