HCSGD entry for TGFB2

1. General information

Official gene symbolTGFB2
Entrez ID7042
Gene full nametransforming growth factor, beta 2
Other gene symbolsLDS4 TGF-beta2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000902Cell morphogenesisIDAbiological_process
GO:0001502Cartilage condensationIEAbiological_process
GO:0001525AngiogenesisTASbiological_process
GO:0001540Beta-amyloid bindingIDAmolecular_function
GO:0001654Eye developmentIDAbiological_process
GO:0001666Response to hypoxiaIMPbiological_process
GO:0001837Epithelial to mesenchymal transitionIDA TASbiological_process
GO:0001942Hair follicle developmentIDA ISSbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0003007Heart morphogenesisIDAbiological_process
GO:0004702Receptor signaling protein serine/threonine kinase activityIDAmolecular_function
GO:0005102Receptor bindingIMPmolecular_function
GO:0005114Type II transforming growth factor beta receptor bindingIDA IPImolecular_function
GO:0005125Cytokine activityTASmolecular_function
GO:0005160Transforming growth factor beta receptor bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0007184SMAD protein import into nucleusIDAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007435Salivary gland morphogenesisIEPbiological_process
GO:0007507Heart developmentIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008219Cell deathIDAbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008347Glial cell migrationIDAbiological_process
GO:0009611Response to woundingIEPbiological_process
GO:0009790Embryo developmentTASbiological_process
GO:0010002Cardioblast differentiationIDAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010634Positive regulation of epithelial cell migrationIDAbiological_process
GO:0010693Negative regulation of alkaline phosphatase activityIDAbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0010936Negative regulation of macrophage cytokine productionIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0016049Cell growthIEAbiological_process
GO:0016477Cell migrationIDAbiological_process
GO:0022601Menstrual cycle phaseIEPbiological_process
GO:0023014Signal transduction by phosphorylationIDAbiological_process
GO:0030097HemopoiesisISSbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIDAbiological_process
GO:0030307Positive regulation of cell growthIDAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030424AxonISScellular_component
GO:0030593Neutrophil chemotaxisISS TASbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0031069Hair follicle morphogenesisISSbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0032147Activation of protein kinase activityIDAbiological_process
GO:0032570Response to progesteroneIDAbiological_process
GO:0032874Positive regulation of stress-activated MAPK cascadeIDAbiological_process
GO:0032909Regulation of transforming growth factor beta2 productionIMPbiological_process
GO:0033630Positive regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0042060Wound healingISSbiological_process
GO:0042416Dopamine biosynthetic processISSbiological_process
GO:0042476OdontogenesisNASbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0042637CatagenIDAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043025Neuronal cell bodyISScellular_component
GO:0043525Positive regulation of neuron apoptotic processIDAbiological_process
GO:0045216Cell-cell junction organizationIDAbiological_process
GO:0045726Positive regulation of integrin biosynthetic processIDAbiological_process
GO:0045778Positive regulation of ossificationIEPbiological_process
GO:0045787Positive regulation of cell cycleISSbiological_process
GO:0045823Positive regulation of heart contractionIDAbiological_process
GO:0046982Protein heterodimerization activityTASmolecular_function
GO:0048103Somatic stem cell divisionISSbiological_process
GO:0048566Embryonic digestive tract developmentIEPbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0048666Neuron developmentISSbiological_process
GO:0048699Generation of neuronsTASbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIDA IMPbiological_process
GO:0050714Positive regulation of protein secretionIDAbiological_process
GO:0050777Negative regulation of immune responseTASbiological_process
GO:0050778Positive regulation of immune responseISSbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0051795Positive regulation of catagenIDAbiological_process
GO:0051891Positive regulation of cardioblast differentiationIDAbiological_process
GO:0060038Cardiac muscle cell proliferationIDAbiological_process
GO:0060317Cardiac epithelial to mesenchymal transitionIDAbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0070237Positive regulation of activation-induced cell death of T cellsIEAbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00376921090.04649028150.16452636820.4043855585

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2476110732
GSE13712_SHEARUp0.2074883204
GSE13712_STATICUp1.3282463095
GSE19018Up1.0020079690
GSE19899_A1Down-0.2173644540
GSE19899_A2Up0.9755367410
PubMed_21979375_A1Up0.9191927137
PubMed_21979375_A2Up1.6828795681
GSE35957Down-1.6837117975
GSE36640Up2.9272439279
GSE54402Down-1.7909806136
GSE9593Down-0.2764906472
GSE43922Down-0.0594530073
GSE24585Down-1.0372873149
GSE37065Up0.0200737844
GSE28863_A1Up0.3112142658
GSE28863_A2Up1.0530618708
GSE28863_A3Up0.3855793251
GSE28863_A4Up0.0319229601
GSE48662Up0.4572965851

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-141-3pMIMAT0000432MIRT002285Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI18483486
hsa-miR-335-5pMIMAT0000765MIRT017363MicroarrayFunctional MTI (Weak)18185580
hsa-miR-375MIMAT0000728MIRT019708MicroarrayFunctional MTI (Weak)20215506
hsa-miR-21-5pMIMAT0000076MIRT030844MicroarrayFunctional MTI (Weak)18591254
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-141-3pMIMAT00004321hsa-miR-141{Western blot}{overexpression by miRNA precursor transfection}18483486
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23358854Keratinocytes from GU-OSCC produced high levels of reactive oxygen species (ROS) and this was associated with an increase in the production of transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 in stromal fibroblasts
20554622Transforming growth factor (TGF)-beta2 is thought to be involved in the pathologic changes of the trabecular meshwork (TM) of POAG eyes
20554622The goal of this study was to determine whether TGF-beta2 triggers senescence-associated changes in human TM cells in vitro
20554622Lipid peroxidation was assessed after TGF-beta2 treatment
20554622RESULTS: TGF-beta2 increased SA-beta-Gal activity, lipid peroxidation, and the mRNA expressions of Apo J, SM22, and SPARC
20554622TGF-beta2 increased p16 mRNA and protein expression, which was paralleled by a downregulation of pRb protein
20554622There was no effect on p21 mRNA and protein expression after exposure to TGF-beta2
20554622CONCLUSIONS: TGF-beta2 induces senescence-associated TM changes and activates the senescence-related p16-pRb signal transduction pathway in vitro
20554622Thus, minimizing TGF-beta2 levels may help to prevent the ageing process in the TM as seen in POAG
20551174Lymphomas that arise express high amounts of transforming growth factor beta-2 (TGFbeta-2) and TGFbeta-3
19171648CONCLUSIONS: Oxidative stress, TGF-beta1, and TGF-beta2 are capable of inducing cellular senescence in cultured human RPE cells
17532297FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2
17532297Furthermore, the levels of TGF-betas mRNA expression in hMSCs were increased by long-term culture, but FGF-2 suppressed the increase of TGF-beta2 mRNA expression due to long-term culture
17532297These results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-beta2 expression
17473528The mRNA expressions of TGFbeta1, TGFbeta2, and TGFbeta receptor type I (TGFbetaRI) in hMSCs increased with the length of cell culture
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