HCSGD entry for TGFBR1
1. General information
| Official gene symbol | TGFBR1 |
|---|---|
| Entrez ID | 7046 |
| Gene full name | transforming growth factor, beta receptor 1 |
| Other gene symbols | AAT5 ACVRLK4 ALK-5 ALK5 LDS1A LDS2A MSSE SKR4 TGFR-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | IDA | biological_process |
| GO:0001501 | Skeletal system development | ISS | biological_process |
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001701 | In utero embryonic development | ISS | biological_process |
| GO:0001822 | Kidney development | IEA ISS | biological_process |
| GO:0001824 | Blastocyst development | IEA | biological_process |
| GO:0001837 | Epithelial to mesenchymal transition | IDA | biological_process |
| GO:0001937 | Negative regulation of endothelial cell proliferation | IEA | biological_process |
| GO:0002088 | Lens development in camera-type eye | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004675 | Transmembrane receptor protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005024 | Transforming growth factor beta-activated receptor activity | IC IDA IEA IMP | molecular_function |
| GO:0005025 | Transforming growth factor beta receptor activity, type I | IDA | molecular_function |
| GO:0005114 | Type II transforming growth factor beta receptor binding | IDA IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005923 | Tight junction | IDA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA IMP | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IC IDA IEA IMP TAS | biological_process |
| GO:0007507 | Heart development | IEA ISS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0008354 | Germ cell migration | IEA ISS | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA ISS | biological_process |
| GO:0010468 | Regulation of gene expression | IEA | biological_process |
| GO:0010862 | Positive regulation of pathway-restricted SMAD protein phosphorylation | IDA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IDA | biological_process |
| GO:0019838 | Growth factor binding | IPI | molecular_function |
| GO:0030199 | Collagen fibril organization | IEA ISS | biological_process |
| GO:0030307 | Positive regulation of cell growth | IDA | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0031396 | Regulation of protein ubiquitination | IDA | biological_process |
| GO:0032331 | Negative regulation of chondrocyte differentiation | IEA ISS | biological_process |
| GO:0042060 | Wound healing | TAS | biological_process |
| GO:0043062 | Extracellular structure organization | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0043393 | Regulation of protein binding | IEA | biological_process |
| GO:0043542 | Endothelial cell migration | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0046332 | SMAD binding | IDA IEA IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048538 | Thymus development | IEA ISS | biological_process |
| GO:0048663 | Neuron fate commitment | IEA ISS | biological_process |
| GO:0048701 | Embryonic cranial skeleton morphogenesis | IEA ISS | biological_process |
| GO:0048705 | Skeletal system morphogenesis | ISS | biological_process |
| GO:0048762 | Mesenchymal cell differentiation | TAS | biological_process |
| GO:0048844 | Artery morphogenesis | IEA ISS | biological_process |
| GO:0048870 | Cell motility | IMP | biological_process |
| GO:0050431 | Transforming growth factor beta binding | IDA IEA IMP IPI | molecular_function |
| GO:0051272 | Positive regulation of cellular component movement | IMP | biological_process |
| GO:0051491 | Positive regulation of filopodium assembly | IEA | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IDA | biological_process |
| GO:0060017 | Parathyroid gland development | IEA ISS | biological_process |
| GO:0060021 | Palate development | IEA ISS | biological_process |
| GO:0060037 | Pharyngeal system development | IEA ISS | biological_process |
| GO:0060389 | Pathway-restricted SMAD protein phosphorylation | IDA | biological_process |
| GO:0060391 | Positive regulation of SMAD protein import into nucleus | IDA | biological_process |
| GO:0070022 | Transforming growth factor beta receptor homodimeric complex | IC | cellular_component |
| GO:0070411 | I-SMAD binding | IPI | molecular_function |
| GO:0070723 | Response to cholesterol | IDA IEA | biological_process |
| GO:0071560 | Cellular response to transforming growth factor beta stimulus | IDA | biological_process |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IDA | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2167769766 | 0.0452683865 | 0.8956794795 | 0.3995671362 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5403223534 |
| GSE13712_SHEAR | Up | 0.4540617008 |
| GSE13712_STATIC | Up | 0.1139755271 |
| GSE19018 | Down | -0.6945659022 |
| GSE19899_A1 | Down | -0.1238780330 |
| GSE19899_A2 | Down | -0.5636768458 |
| PubMed_21979375_A1 | Down | -0.0466214364 |
| PubMed_21979375_A2 | Up | 0.0761943699 |
| GSE35957 | Up | 0.8263154196 |
| GSE36640 | Down | -0.6985949727 |
| GSE54402 | Down | -1.3010794587 |
| GSE9593 | Down | -0.6471953100 |
| GSE43922 | Up | 0.1874053043 |
| GSE24585 | Up | 0.5150635919 |
| GSE37065 | Down | -0.3010979090 |
| GSE28863_A1 | Up | 0.3682902180 |
| GSE28863_A2 | Up | 0.9266850072 |
| GSE28863_A3 | Down | -0.3278918606 |
| GSE28863_A4 | Down | -0.0243726267 |
| GSE48662 | Up | 0.1336767186 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline | DB03921 | EXPT02712 |
| Naphthyridine Inhibitor | DB04434 | EXPT00199 |
| 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole | DB04480 | EXPT00236 |
| N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide | DB07152 | - |
| 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine | DB07267 | - |
| N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine | DB08450 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7c-5p | MIMAT0000064 | MIRT000687 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19841744 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT003271 | Luciferase reporter assay | Non-Functional MTI | 20056717 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT004650 | Luciferase reporter assay//Western blot | Functional MTI | 20054641 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT004650 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-140-5p | MIMAT0000431 | MIRT007379 | Luciferase reporter assay | Functional MTI | 23401231 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT021634 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027382 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027865 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032178 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22037217 | However, Pten-deficient mice developed full-penetrance HNSCC in combination with type I TGF-beta receptor (Tgfbr1) deletion |
| 22037217 | Molecular analysis revealed enhanced cell proliferation, decreased apoptosis, and increased expression of CCND1 in the basal layer of the head and neck epithelia, as well as in the tumors of Tgfbr1/Pten double conditional knockout (2cKO) mice |
| 22037217 | This suggests that the Tgfbr1/Pten 2cKO mouse model is suitable for preclinical intervention, and that it has significant implications in the development of diagnostic cancer biomarkers and effective strategies for prevention and treatment of HNSCCs |
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