HCSGD entry for TGM2
1. General information
| Official gene symbol | TGM2 |
|---|---|
| Entrez ID | 7052 |
| Gene full name | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) |
| Other gene symbols | G-ALPHA-h GNAH TG2 TGC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001974 | Blood vessel remodeling | IEA | biological_process |
| GO:0003810 | Protein-glutamine gamma-glutamyltransferase activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0018149 | Peptide cross-linking | IEA | biological_process |
| GO:0018153 | Isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine | IEA | biological_process |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IEA | biological_process |
| GO:0043277 | Apoptotic cell clearance | IDA | biological_process |
| GO:0045785 | Positive regulation of cell adhesion | IEA ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | IEA | biological_process |
| GO:0050729 | Positive regulation of inflammatory response | IEA | biological_process |
| GO:0051260 | Protein homooligomerization | IEA | biological_process |
| GO:0051482 | Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | IEA | biological_process |
| GO:0060445 | Branching involved in salivary gland morphogenesis | IEA | biological_process |
| GO:0060662 | Salivary gland cavitation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0007001672 | 0.7837364424 | 0.0758399177 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.2645898501 |
| GSE13712_SHEAR | Down | -0.1978383015 |
| GSE13712_STATIC | Up | 0.1182488488 |
| GSE19018 | Up | 0.4391561857 |
| GSE19899_A1 | Up | 0.4278738667 |
| GSE19899_A2 | Up | 3.0442997303 |
| PubMed_21979375_A1 | Up | 0.9941540377 |
| PubMed_21979375_A2 | Up | 2.3929823448 |
| GSE35957 | Up | 0.5405871285 |
| GSE36640 | Up | 0.5770715704 |
| GSE54402 | Up | 1.2064029632 |
| GSE9593 | Down | -0.2139771804 |
| GSE43922 | Up | 1.0525630492 |
| GSE24585 | Up | 0.2557785496 |
| GSE37065 | Down | -0.1316600345 |
| GSE28863_A1 | Down | -0.7221899709 |
| GSE28863_A2 | Down | -0.0542297396 |
| GSE28863_A3 | Up | 0.6732429443 |
| GSE28863_A4 | Down | -0.0532792704 |
| GSE48662 | Down | -0.3544825758 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019710 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020574 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025339 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025649 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028406 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27165830 | Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney |
| 27165830 | EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins |
| 27165830 | Here we tested whether EST and TG2 play a role in the fibrosis of aging |
| 27165830 | In wild-type mice, aging kidneys exhibited a 2- to 4-fold increase in TG2 paralleled by increased cross-linked extracellular matrix proteins and fibrosis |
| 27165830 | Upregulated TG2 and impaired renal function were apparent with EST delivery combined with folic acid-induced nephropathy |
| 27165830 | Subcapsular injection of TG2 and/or EST into kidneys of young mice not only induced interstitial fibrosis, but also increased the proportion of senescent cells |
| 27165830 | Thus, kidney fibrosis in aging may represent a natural outcome of upregulated EST and TG2, but more likely it appears to be a result of cumulative stresses occurring on the background of synergistically acting geronic (aging) proteins, EST and TG2 |
| 10051854 | Aging process is accompanied by increase of transglutaminase C |
| 9415111 | Apoptosis was analyzed by cellular morphology and by the expression of tissue transglutaminase |
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