HCSGD entry for TMSB4X
1. General information
| Official gene symbol | TMSB4X |
|---|---|
| Entrez ID | 7114 |
| Gene full name | thymosin beta 4, X-linked |
| Other gene symbols | FX PTMB4 TB4X TMSB4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031093 | Platelet alpha granule lumen | TAS | cellular_component |
| GO:0042989 | Sequestering of actin monomers | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8509155921 | 0.4297920976 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0736745741 |
| GSE13712_SHEAR | Up | 0.1341607788 |
| GSE13712_STATIC | Up | 0.1471001089 |
| GSE19018 | Down | -0.1173078525 |
| GSE19899_A1 | Up | 0.0113045176 |
| GSE19899_A2 | Down | -0.0086789854 |
| PubMed_21979375_A1 | Down | -0.4355436916 |
| PubMed_21979375_A2 | Down | -0.1127451835 |
| GSE35957 | Up | 0.0374027795 |
| GSE36640 | Down | -0.0942088208 |
| GSE54402 | Down | -0.1547349781 |
| GSE9593 | Up | 0.1161420914 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.3419797643 |
| GSE28863_A2 | Up | 0.2098941678 |
| GSE28863_A3 | Down | -0.3840441964 |
| GSE28863_A4 | Up | 0.1784754234 |
| GSE48662 | Down | -0.4581963927 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001845 | Reporter assay;Other | Functional MTI | 15951802 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26021512 | Thymosin Beta-4 Recombinant Adeno-associated Virus Enhances Human Nucleus Pulposus Cell Proliferation and Reduces Cell Apoptosis and Senescence |
| 26021512 | BACKGROUND: Thymosin beta-4 (TB-4) is considered key roles in tissue development, maintenance and pathological processes |
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