HCSGD entry for TNFAIP3

1. General information

Official gene symbolTNFAIP3
Entrez ID7128
Gene full nametumor necrosis factor, alpha-induced protein 3
Other gene symbolsA20 OTUD7C TNFA1P2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001922B-1 B cell homeostasisIEA ISSbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0002237Response to molecule of bacterial originIDA IEAbiological_process
GO:0002634Regulation of germinal center formationIEA ISSbiological_process
GO:0002677Negative regulation of chronic inflammatory responseIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0004221Ubiquitin thiolesterase activityIMPmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0004843Ubiquitin-specific protease activityIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005764LysosomeIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016579Protein deubiquitinationIEA TASbiological_process
GO:0019900Kinase bindingIEAmolecular_function
GO:0031397Negative regulation of protein ubiquitinationIDAbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0032495Response to muramyl dipeptideIEAbiological_process
GO:0032691Negative regulation of interleukin-1 beta productionIEAbiological_process
GO:0032703Negative regulation of interleukin-2 productionIMPbiological_process
GO:0032715Negative regulation of interleukin-6 productionIEA ISSbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEA ISSbiological_process
GO:0034136Negative regulation of toll-like receptor 2 signaling pathwayNASbiological_process
GO:0034140Negative regulation of toll-like receptor 3 signaling pathwayIDAbiological_process
GO:0034144Negative regulation of toll-like receptor 4 signaling pathwayNASbiological_process
GO:0034148Negative regulation of toll-like receptor 5 signaling pathwayIEAbiological_process
GO:0035871Protein K11-linked deubiquitinationIDAbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0043124Negative regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043130Ubiquitin bindingIPImolecular_function
GO:0043621Protein self-associationIDAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045732Positive regulation of protein catabolic processIDAbiological_process
GO:0045736Negative regulation of cyclin-dependent protein serine/threonine kinase activityIEAbiological_process
GO:0045779Negative regulation of bone resorptionNASbiological_process
GO:0045824Negative regulation of innate immune responseIEA ISSbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIDAbiological_process
GO:0050691Regulation of defense response to virus by hostNASbiological_process
GO:0050728Negative regulation of inflammatory responseISSbiological_process
GO:0050869Negative regulation of B cell activationIEA ISSbiological_process
GO:0051259Protein oligomerizationNASbiological_process
GO:0060548Negative regulation of cell deathIEAbiological_process
GO:0061043Regulation of vascular wound healingNASbiological_process
GO:0070301Cellular response to hydrogen peroxideIEA ISSbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0070429Negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathwayIEAbiological_process
GO:0070433Negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathwayIEAbiological_process
GO:0070536Protein K63-linked deubiquitinationIDAbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0071108Protein K48-linked deubiquitinationIDAbiological_process
GO:0071222Cellular response to lipopolysaccharideIDAbiological_process
GO:0072573Tolerance induction to lipopolysaccharideIMPbiological_process
GO:0090291Negative regulation of osteoclast proliferationNASbiological_process
GO:1902042Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIDAbiological_process
GO:2000347Positive regulation of hepatocyte proliferationIEAbiological_process
GO:2000349Negative regulation of CD40 signaling pathwayIMPbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00049663010.16020014820.06284519230.7732675775

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7262654769
GSE13712_SHEARDown-0.0304912563
GSE13712_STATICUp0.2432932844
GSE19018Down-0.5727247215
GSE19899_A1Up1.3976144391
GSE19899_A2Up4.4206804922
PubMed_21979375_A1Up3.5079370475
PubMed_21979375_A2Up3.0730331123
GSE35957Down-0.6605289695
GSE36640Down-1.8184684694
GSE54402Up0.6882620874
GSE9593Up0.5958653330
GSE43922Up1.6422758957
GSE24585Down-0.6281746897
GSE37065Up1.0482297376
GSE28863_A1Down-0.4402200055
GSE28863_A2Up0.8414596397
GSE28863_A3Down-0.1568544548
GSE28863_A4Up0.1457534686
GSE48662Down-0.2856670824

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT006471qRT-PCR//Western blotFunctional MTI22550173
hsa-miR-125b-5pMIMAT0000423MIRT006472qRT-PCR//Western blotFunctional MTI22550173
hsa-miR-29a-3pMIMAT0000086MIRT006380Luciferase reporter assayFunctional MTI21763284
hsa-miR-21-5pMIMAT0000076MIRT005955Luciferase reporter assayNon-Functional MTI21131358
hsa-miR-26b-5pMIMAT0000083MIRT029863MicroarrayFunctional MTI (Weak)19088304
hsa-miR-24-3pMIMAT0000080MIRT030581MicroarrayFunctional MTI (Weak)19748357
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.