HCSGD entry for TNNC1
1. General information
| Official gene symbol | TNNC1 |
|---|---|
| Entrez ID | 7134 |
| Gene full name | troponin C type 1 (slow) |
| Other gene symbols | CMD1Z CMH13 TN-C TNC TNNC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002086 | Diaphragm contraction | IEA | biological_process |
| GO:0005509 | Calcium ion binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005861 | Troponin complex | IDA | cellular_component |
| GO:0006937 | Regulation of muscle contraction | IDA TAS | biological_process |
| GO:0010038 | Response to metal ion | IEA | biological_process |
| GO:0030049 | Muscle filament sliding | TAS | biological_process |
| GO:0031013 | Troponin I binding | IDA IPI | molecular_function |
| GO:0031014 | Troponin T binding | IPI | molecular_function |
| GO:0032972 | Regulation of muscle filament sliding speed | IEA ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043292 | Contractile fiber | IEA | cellular_component |
| GO:0043462 | Regulation of ATPase activity | IEA ISS | biological_process |
| GO:0048306 | Calcium-dependent protein binding | IPI | molecular_function |
| GO:0051015 | Actin filament binding | IEA ISS | molecular_function |
| GO:0055010 | Ventricular cardiac muscle tissue morphogenesis | IMP | biological_process |
| GO:0060048 | Cardiac muscle contraction | IEA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5730545116 | 0.5639919380 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1167332009 |
| GSE13712_SHEAR | Up | 0.1523685405 |
| GSE13712_STATIC | Up | 0.0210190203 |
| GSE19018 | Down | -0.0094298381 |
| GSE19899_A1 | Up | 0.1205890489 |
| GSE19899_A2 | Down | -0.1087116862 |
| PubMed_21979375_A1 | Up | 0.7350668658 |
| PubMed_21979375_A2 | Up | 0.0155674362 |
| GSE35957 | Up | 0.2293558050 |
| GSE36640 | Up | 0.0163899890 |
| GSE54402 | Down | -0.1450376198 |
| GSE9593 | Down | -0.0175111577 |
| GSE43922 | Up | 0.0224304874 |
| GSE24585 | Down | -0.2965133872 |
| GSE37065 | Down | -0.1529220102 |
| GSE28863_A1 | Down | -0.0581137597 |
| GSE28863_A2 | Down | -0.2217976939 |
| GSE28863_A3 | Up | 0.1672392408 |
| GSE28863_A4 | Up | 0.2036759320 |
| GSE48662 | Down | -0.2690730993 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Levosimendan | DB00922 | APRD01296 |
| Bepridil | DB01244 | APRD00727 |
| Calcium | DB01373 | - |
| Aluminium monostearate | DB01375 | - |
| 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One | DB03944 | EXPT01339 |
| N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide | DB04513 | EXPT03246 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017278 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
