HCSGD entry for TRPC4
1. General information
| Official gene symbol | TRPC4 |
|---|---|
| Entrez ID | 7223 |
| Gene full name | transient receptor potential cation channel, subfamily C, member 4 |
| Other gene symbols | HTRP-4 HTRP4 TRP4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005262 | Calcium channel activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005901 | Caveola | IEA | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0006816 | Calcium ion transport | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008013 | Beta-catenin binding | IPI | molecular_function |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0014051 | Gamma-aminobutyric acid secretion | IEA | biological_process |
| GO:0015279 | Store-operated calcium channel activity | IMP | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IDA | cellular_component |
| GO:0030863 | Cortical cytoskeleton | IDA | cellular_component |
| GO:0034704 | Calcium channel complex | IDA | cellular_component |
| GO:0045296 | Cadherin binding | IPI | molecular_function |
| GO:0070509 | Calcium ion import | IDA | biological_process |
| GO:0070679 | Inositol 1,4,5 trisphosphate binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5220285513 | 0.0067062270 | 0.9999902473 | 0.1643525140 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0387793164 |
| GSE13712_SHEAR | Up | 0.1502770585 |
| GSE13712_STATIC | Down | -0.1089204674 |
| GSE19018 | Up | 0.0871194592 |
| GSE19899_A1 | Down | -0.1430282841 |
| GSE19899_A2 | Down | -0.5569492453 |
| PubMed_21979375_A1 | Up | 0.3474463408 |
| PubMed_21979375_A2 | Up | 0.0692529396 |
| GSE35957 | Up | 2.5332079737 |
| GSE36640 | Down | -0.1163373304 |
| GSE54402 | Up | 0.2294756007 |
| GSE9593 | Up | 0.0197547546 |
| GSE43922 | Down | -0.8086366923 |
| GSE24585 | Down | -0.7616697932 |
| GSE37065 | Up | 0.0972792807 |
| GSE28863_A1 | Down | -0.4502031556 |
| GSE28863_A2 | Down | -1.2727372506 |
| GSE28863_A3 | Down | -0.7765081406 |
| GSE28863_A4 | Up | 0.3686229368 |
| GSE48662 | Down | -1.1238677016 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029916 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24496748 | Additionally, expression analysis identified PLEC, C8orf48, TRPC4, and ZNF14, as differentially regulated genes in senescent hMSCs that were similarly regulated in those hMSCs which failed to produce a therapeutic effect in a GVHD trial |
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