HCSGD entry for TUBA4A

1. General information

Official gene symbolTUBA4A
Entrez ID7277
Gene full nametubulin, alpha 4a
Other gene symbolsH2-ALPHA TUBA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000226Microtubule cytoskeleton organizationIEAbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0005200Structural constituent of cytoskeletonIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIDA IEAcellular_component
GO:0005881Cytoplasmic microtubuleIEAcellular_component
GO:0006457Protein foldingTASbiological_process
GO:0007017Microtubule-based processIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0051258Protein polymerizationIEAbiological_process
GO:0071353Cellular response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12868365560.07766973520.72840483870.5275319659

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5793841753
GSE13712_SHEARDown-0.6557886284
GSE13712_STATICDown-0.1770231208
GSE19018Up0.6617367747
GSE19899_A1Down-0.4521173706
GSE19899_A2Down-0.1469339448
PubMed_21979375_A1Down-0.6886088926
PubMed_21979375_A2Down-0.9581250514
GSE35957Down-0.4527103231
GSE36640Up0.8732624574
GSE54402Down-0.0008417157
GSE9593Down-0.3994185333
GSE43922Down-0.2798904989
GSE24585Up0.4949363041
GSE37065Up0.7771889521
GSE28863_A1Down-0.2594312448
GSE28863_A2Up0.1237375715
GSE28863_A3Up0.2005577883
GSE28863_A4Down-0.0049878998
GSE48662Down-0.0627568226

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL210722CHEMBL20707P68366
CHEMBL67CHEMBL20707P68366
CHEMBL198700CHEMBL20707P68366
CHEMBL210806CHEMBL20707P68366
CHEMBL372849CHEMBL20707P68366
CHEMBL67CHEMBL20707P68366
CHEMBL204241CHEMBL20707P68366
CHEMBL205487CHEMBL20707P68366
CHEMBL208272CHEMBL20707P68366
CHEMBL198808CHEMBL20707P68366
CHEMBL369927CHEMBL20707P68366
CHEMBL381122CHEMBL20707P68366
CHEMBL67CHEMBL20707P68366
CHEMBL61CHEMBL20707P68366
CHEMBL203974CHEMBL20707P68366
CHEMBL196966CHEMBL20707P68366
CHEMBL198522CHEMBL20707P68366
CHEMBL381049CHEMBL20707P68366
CHEMBL107CHEMBL20707P68366
CHEMBL204710CHEMBL20707P68366
CHEMBL203062CHEMBL20707P68366
CHEMBL206073CHEMBL20707P68366
CHEMBL205166CHEMBL20707P68366
CHEMBL383065CHEMBL20707P68366
CHEMBL67CHEMBL20707P68366
CHEMBL381852CHEMBL20707P68366
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  • Drugs

Name

Drug

Accession number

VincristineDB00541 APRD00495
PodofiloxDB01179 APRD01189 | DB08417
Epothilone DDB01873 EXPT01350
Epothilone BDB03010 EXPT01349
CYT997DB05147 -
S-8184DB05281 -
CabazitaxelDB06772 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.