HCSGD entry for CCR2

1. General information

Official gene symbolCCR2
Entrez ID729230
Gene full namechemokine (C-C motif) receptor 2
Other gene symbolsCC-CKR-2 CCR-2 CCR2A CCR2B CD192 CKR2 CKR2A CKR2B CMKBR2 MCP-1-R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001974Blood vessel remodelingIEA ISSbiological_process
GO:0002407Dendritic cell chemotaxisTASbiological_process
GO:0002827Positive regulation of T-helper 1 type immune responseISSbiological_process
GO:0002829Negative regulation of type 2 immune responseISSbiological_process
GO:0004950Chemokine receptor activityTASmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolISScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006874Cellular calcium ion homeostasisISSbiological_process
GO:0006935ChemotaxisIEA TASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIEA TASbiological_process
GO:0006968Cellular defense responseTASbiological_process
GO:0007194Negative regulation of adenylate cyclase activityTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0009611Response to woundingTASbiological_process
GO:0010574Regulation of vascular endothelial growth factor productionISSbiological_process
GO:0010820Positive regulation of T cell chemotaxisISSbiological_process
GO:0016021Integral component of membraneIEA TAScellular_component
GO:0016032Viral processIEAbiological_process
GO:0016493C-C chemokine receptor activityIEAmolecular_function
GO:0016525Negative regulation of angiogenesisISSbiological_process
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0019725Cellular homeostasisISSbiological_process
GO:0030425DendriteISScellular_component
GO:0031727CCR2 chemokine receptor bindingIDAmolecular_function
GO:0032729Positive regulation of interferon-gamma productionISSbiological_process
GO:0032743Positive regulation of interleukin-2 productionISSbiological_process
GO:0035705T-helper 17 cell chemotaxisISSbiological_process
GO:0042535Positive regulation of tumor necrosis factor biosynthetic processISSbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043025Neuronal cell bodyISScellular_component
GO:0043204PerikaryonISScellular_component
GO:0043310Negative regulation of eosinophil degranulationISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046641Positive regulation of alpha-beta T cell proliferationISSbiological_process
GO:0048471Perinuclear region of cytoplasmISScellular_component
GO:0050729Positive regulation of inflammatory responseISSbiological_process
GO:0050870Positive regulation of T cell activationISSbiological_process
GO:0070098Chemokine-mediated signaling pathwayISSbiological_process
GO:0090026Positive regulation of monocyte chemotaxisIDA IEA ISSbiological_process
GO:0090265Positive regulation of immune complex clearance by monocytes and macrophagesISSbiological_process
GO:2000439Positive regulation of monocyte extravasationISSbiological_process
GO:2000451Positive regulation of CD8-positive, alpha-beta T cell extravasationISSbiological_process
GO:2000464Positive regulation of astrocyte chemotaxisIDAbiological_process
GO:2000473Positive regulation of hematopoietic stem cell migrationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47690068010.81860631430.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0062587170
GSE13712_SHEARDown-0.1137110108
GSE13712_STATICUp0.0141445444
GSE19018Up0.0173352576
GSE19899_A1Up0.0634942609
GSE19899_A2Down-0.0213304449
PubMed_21979375_A1Down-0.0188312560
PubMed_21979375_A2Down-0.0388607643
GSE35957Up0.1526140476
GSE36640Up0.0213764563
GSE54402Up0.0561204371
GSE9593Down-0.1136681574
GSE43922Up0.0239006196
GSE24585Up0.1246152817
GSE37065Down-0.0785238836
GSE28863_A1Up0.2527543408
GSE28863_A2Up0.0414615677
GSE28863_A3Up0.2997663300
GSE28863_A4Up0.2136791577
GSE48662Down-0.0503593240

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

INCB3284DB05130 -
CCX915DB05159 -
MLN-1202DB05486 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018230MicroarrayFunctional MTI (Weak)18185580
hsa-miR-744-3pMIMAT0004946MIRT037379CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26573462RESULTS: We found that monocyte chemoattractant protein-1 (MCP-1) was secreted as a dominant component of the SASP during expansion of UCB-MSCs and reinforced senescence via its cognate receptor chemokine (c-c motif) receptor 2 (CCR2) by activating the ROS-p38-MAPK-p53/p21 signaling cascade in both an autocrine and paracrine manner
26573462Accordingly, knockdown of CCR2 in UCB-MSCs significantly improved their therapeutic ability to alleviate airway inflammation in an experimental allergic asthma model
25808810Furthermore, CCL2 was found to enhance stem cell migration, and the inhibition of CCR2, a receptor for CCL2, reduced stem cell migration
24185682Given senescent biliary epithelial cells (BECs) in damaged small bile ducts in primary biliary cirrhosis (PBC) show increased expression of chemokines CCL2 and CX3CL1 as SASP, we further examined an involvement of CCL2/CCR2 and CX3CL1/CX3CR1 systems in the pathogenesis of PBC
24185682METHODS: We examined immunohistochemically the expression of CCR2, CX3CR1, CCL2 and CX3CL1 in livers taken from the patients with PBC (n = 45) and control livers (n = 78), such as chronic viral hepatitis (CVH; n = 39)
24185682CCR2 or CX3CR1-expressing cells were characterized by double immunofluorescence with CD3, CD4, CD8, CD56 or CD68
24185682RESULTS: CCR2 is expressed in round cells, epithelioid cells and dendritic cells and most CCR2-positive cells were CD68-positive
24185682CONCLUSION: CCL2 and CX3CL1 produced by senescent BECs may promote infiltration of corresponding CCR2 and CX3CR1-expressing cells and further aggravate inflammation in bile duct lesion in PBC
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