HCSGD entry for UBE2A
1. General information
| Official gene symbol | UBE2A |
|---|---|
| Entrez ID | 7319 |
| Gene full name | ubiquitin-conjugating enzyme E2A |
| Other gene symbols | HHR6A MRXS30 MRXSN RAD6A UBC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | TAS | biological_process |
| GO:0000785 | Chromatin | ISS | cellular_component |
| GO:0000790 | Nuclear chromatin | IEA | cellular_component |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001741 | XY body | IEA | cellular_component |
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006281 | DNA repair | IGI | biological_process |
| GO:0006301 | Postreplication repair | NAS | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | NAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0009411 | Response to UV | IGI | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0033503 | HULC complex | IDA | cellular_component |
| GO:0033522 | Histone H2A ubiquitination | IDA | biological_process |
| GO:0051865 | Protein autoubiquitination | IDA | biological_process |
| GO:0060135 | Maternal process involved in female pregnancy | IEA | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | IDA | biological_process |
| GO:0070979 | Protein K11-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1515664868 | 0.9673682687 | 0.7773298871 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3634319206 |
| GSE13712_SHEAR | Up | 0.2442384580 |
| GSE13712_STATIC | Up | 0.1055299587 |
| GSE19018 | Up | 0.0441956206 |
| GSE19899_A1 | Up | 0.1486398945 |
| GSE19899_A2 | Up | 0.1127400896 |
| PubMed_21979375_A1 | Up | 0.2018331397 |
| PubMed_21979375_A2 | Up | 0.0589933470 |
| GSE35957 | Down | -0.1543735084 |
| GSE36640 | Up | 0.2728362266 |
| GSE54402 | Up | 0.1786465562 |
| GSE9593 | Up | 0.2105221903 |
| GSE43922 | Up | 0.0591264010 |
| GSE24585 | Up | 0.3738832919 |
| GSE37065 | Up | 0.1128159978 |
| GSE28863_A1 | Down | -0.1415564824 |
| GSE28863_A2 | Up | 0.1411544383 |
| GSE28863_A3 | Down | -0.1071428733 |
| GSE28863_A4 | Up | 0.1443048221 |
| GSE48662 | Down | -0.2524364358 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036410 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037559 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050167 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051916 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
