HCSGD entry for UBE2B

1. General information

Official gene symbolUBE2B
Entrez ID7320
Gene full nameubiquitin-conjugating enzyme E2B
Other gene symbolsE2-17kDa HHR6B HR6B RAD6B UBC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000209Protein polyubiquitinationIMPbiological_process
GO:0000785ChromatinISScellular_component
GO:0000790Nuclear chromatinIEAcellular_component
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001741XY bodyIEAcellular_component
GO:0004842Ubiquitin-protein ligase activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005657Replication forkIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006281DNA repairIGIbiological_process
GO:0006301Postreplication repairIDA NASbiological_process
GO:0006344Maintenance of chromatin silencingIEAbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDA NASbiological_process
GO:0006513Protein monoubiquitinationIMPbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007283SpermatogenesisTASbiological_process
GO:0007288Sperm axoneme assemblyIEAbiological_process
GO:0009411Response to UVIGIbiological_process
GO:0010845Positive regulation of reciprocal meiotic recombinationIEAbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0016881Acid-amino acid ligase activityIEAmolecular_function
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0033128Negative regulation of histone phosphorylationIEAbiological_process
GO:0033503HULC complexIDAcellular_component
GO:0033522Histone H2A ubiquitinationIMPbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0043951Negative regulation of cAMP-mediated signalingIDAbiological_process
GO:0050821Protein stabilizationIMPbiological_process
GO:0051026Chiasma assemblyIEAbiological_process
GO:0051865Protein autoubiquitinationIDAbiological_process
GO:0060070Canonical Wnt signaling pathwayISSbiological_process
GO:0070076Histone lysine demethylationIEAbiological_process
GO:0070193Synaptonemal complex organizationIEAbiological_process
GO:0070534Protein K63-linked ubiquitinationIDAbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0070979Protein K11-linked ubiquitinationIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78894953840.48038033890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1197765085
GSE13712_SHEARDown-0.1196259748
GSE13712_STATICDown-0.0634354870
GSE19018Up0.2032806655
GSE19899_A1Down-0.0623758741
GSE19899_A2Down-0.2939885302
PubMed_21979375_A1Up0.0696594606
PubMed_21979375_A2Down-0.1139204121
GSE35957Up0.2805006410
GSE36640Up0.4314692537
GSE54402Up0.1333245515
GSE9593Up0.1359934841
GSE43922Up0.0012203234
GSE24585Up0.0386892138
GSE37065Up0.0093642229
GSE28863_A1Down-0.2287900702
GSE28863_A2Up0.1341117306
GSE28863_A3Down-0.0893799544
GSE28863_A4Down-0.2688647084
GSE48662Down-0.2874482127

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-101-3pMIMAT0000099MIRT027247SequencingFunctional MTI (Weak)20371350
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21835799One well-established method of E6/E7 repression involves the reexpression of the viral E2 protein which is usually deleted in HPV-positive cancer cells
11714633Expression of the E2 protein in these cells repressed HPV E6/E7 expression, activated tumor suppressor pathways, and induced senescence as assessed by growth arrest, morphological changes, senescence-associated beta-galactosidase expression, and increased autofluorescence
Entries Per Page
Displaying Page of