HCSGD entry for UBE2D1

1. General information

Official gene symbolUBE2D1
Entrez ID7321
Gene full nameubiquitin-conjugating enzyme E2D 1
Other gene symbolsE2(17)KB1 SFT UBC4/5 UBCH5 UBCH5A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000151Ubiquitin ligase complexIDAcellular_component
GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0030509BMP signaling pathwayTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07607692340.92651150790.58322003491.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2805324409
GSE13712_SHEARUp0.0551676198
GSE13712_STATICUp0.1249180657
GSE19018Down-0.2369724195
GSE19899_A1Up0.4322908071
GSE19899_A2Up0.3964726471
PubMed_21979375_A1Up0.2412663749
PubMed_21979375_A2Up0.1514559607
GSE35957Down-0.0229782520
GSE36640Down-0.0145705857
GSE54402Up0.3443124938
GSE9593Up0.0089445744
GSE43922Up0.3084259462
GSE24585Down-0.1482418570
GSE37065Up0.1733550244
GSE28863_A1Up0.3232101391
GSE28863_A2Up0.4278863731
GSE28863_A3Down-0.3688666539
GSE28863_A4Up0.1287783524
GSE48662Down-0.1891391114

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT021975MicroarrayFunctional MTI (Weak)17612493
hsa-miR-215-5pMIMAT0000272MIRT024683MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026353MicroarrayFunctional MTI (Weak)19074876
hsa-miR-188-5pMIMAT0000457MIRT044897CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.