HCSGD entry for UBE2N

1. General information

Official gene symbolUBE2N
Entrez ID7334
Gene full nameubiquitin-conjugating enzyme E2N
Other gene symbolsUBC13 UbcH-ben UbcH13
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIDAcellular_component
GO:0000724Double-strand break repair via homologous recombinationIMPbiological_process
GO:0000729DNA double-strand break processingIMPbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006282Regulation of DNA repairTASbiological_process
GO:0006301Postreplication repairIMPbiological_process
GO:0006464Cellular protein modification processTASbiological_process
GO:0006508ProteolysisTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0016567Protein ubiquitinationIMP TASbiological_process
GO:0016574Histone ubiquitinationIMPbiological_process
GO:0016881Acid-amino acid ligase activityIEAmolecular_function
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0031058Positive regulation of histone modificationIMPbiological_process
GO:0031372UBC13-MMS2 complexIDAcellular_component
GO:0033182Regulation of histone ubiquitinationIMPbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035370UBC13-UEV1A complexIDAcellular_component
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMP TASbiological_process
GO:0043130Ubiquitin bindingIDAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045739Positive regulation of DNA repairIMPbiological_process
GO:0050852T cell receptor signaling pathwayIMP TASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0051443Positive regulation of ubiquitin-protein ligase activityIMPbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0070534Protein K63-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99325142280.01813054980.99999024730.2633632450

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1814755074
GSE13712_SHEARDown-0.0939466145
GSE13712_STATICDown-0.0763620539
GSE19018Down-0.4717583785
GSE19899_A1Down-0.3334849660
GSE19899_A2Down-0.1424535525
PubMed_21979375_A1Up0.2401064097
PubMed_21979375_A2Down-0.2830974017
GSE35957Down-0.3668417292
GSE36640Down-0.4673573356
GSE54402Up0.2175693081
GSE9593Down-0.2203893423
GSE43922Down-0.1614906593
GSE24585Down-0.1566961813
GSE37065Down-0.0428493868
GSE28863_A1Down-0.3450679987
GSE28863_A2Down-0.4976239677
GSE28863_A3Down-0.2329335305
GSE28863_A4Down-0.0915863537
GSE48662Down-0.4950867134

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT021990MicroarrayFunctional MTI (Weak)17612493
hsa-miR-221-3pMIMAT0000278MIRT024180SequencingFunctional MTI (Weak)20371350
hsa-miR-96-5pMIMAT0000095MIRT027911SequencingFunctional MTI (Weak)20371350
hsa-miR-877-5pMIMAT0004949MIRT037291CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037679CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045605CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.