HCSGD entry for WNT10B

1. General information

Official gene symbolWNT10B
Entrez ID7480
Gene full namewingless-type MMTV integration site family, member 10B
Other gene symbolsSHFM6 WNT-12
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleIEAbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0002062Chondrocyte differentiationIEPbiological_process
GO:0005102Receptor bindingIEAmolecular_function
GO:0005109Frizzled bindingIBAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceNAScellular_component
GO:0006629Lipid metabolic processIEAbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010469Regulation of receptor activityICbiological_process
GO:0010971Positive regulation of G2/M transition of mitotic cell cycleIEAbiological_process
GO:0014835Myoblast differentiation involved in skeletal muscle regenerationIEAbiological_process
GO:0016055Wnt signaling pathwayIEA IMPbiological_process
GO:0030182Neuron differentiationIBA ISSbiological_process
GO:0030501Positive regulation of bone mineralizationIEAbiological_process
GO:0030858Positive regulation of epithelial cell differentiationIEAbiological_process
GO:0032434Regulation of proteasomal ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0045165Cell fate commitmentIBAbiological_process
GO:0045599Negative regulation of fat cell differentiationIDA IEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045899Positive regulation of RNA polymerase II transcriptional preinitiation complex assemblyIEAbiological_process
GO:0048018Receptor agonist activityICmolecular_function
GO:0048641Regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0048741Skeletal muscle fiber developmentIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050821Protein stabilizationIDAbiological_process
GO:0050909Sensory perception of tasteIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0051885Positive regulation of anagenIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDA IEAbiological_process
GO:0060346Bone trabecula formationIEAbiological_process
GO:0061196Fungiform papilla developmentIEAbiological_process
GO:0071300Cellular response to retinoic acidISSbiological_process
GO:0071320Cellular response to cAMPIEAbiological_process
GO:0071374Cellular response to parathyroid hormone stimulusIEAbiological_process
GO:0071425Hematopoietic stem cell proliferationIDA IEAbiological_process
GO:0071464Cellular response to hydrostatic pressureIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:2000273Positive regulation of receptor activityICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18241360890.57340645490.83618248001.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1113569595
GSE13712_SHEARDown-0.0766151521
GSE13712_STATICDown-0.4317842039
GSE19018Down-0.0382069751
GSE19899_A1Up0.1273211886
GSE19899_A2Up0.4094428013
PubMed_21979375_A1Down-0.2734819875
PubMed_21979375_A2Down-0.0656771066
GSE35957Down-0.0773591151
GSE36640Up0.2551992792
GSE54402Down-0.4067707576
GSE9593Up0.1680837264
GSE43922Up0.2277844645
GSE24585Up0.0980457114
GSE37065Down-0.0426219546
GSE28863_A1Down-0.2123139730
GSE28863_A2Down-0.0484839897
GSE28863_A3Up0.4050453699
GSE28863_A4Up0.0896173507
GSE48662Up1.4872825768

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018883MicroarrayFunctional MTI (Weak)18185580
hsa-miR-98-5pMIMAT0000096MIRT027804MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-148b-3pMIMAT0000759NAhsa-miR-148b21205300
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26056007Effects of Wnt-10b on proliferation and differentiation of murine melanoma cells
26056007In spite of the strong expression of Wnt-10b in melanomas, its role in melanoma cells has not been elucidated
26056007In the present study, the biological effects of Wnt-10b on murine B16F10 (B16) melanoma cells were investigated using conditioned medium from Wnt-10b-producing COS cells (Wnt-CM)
26056007These results suggest that Wnt-10b represses tumor cell properties, such as proliferation and migration of B16 melanoma cells, driving them toward a more differentiated state along a melanocyte lineage
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