HCSGD entry for XPC
1. General information
| Official gene symbol | XPC |
|---|---|
| Entrez ID | 7508 |
| Gene full name | xeroderma pigmentosum, complementation group C |
| Other gene symbols | RAD4 XP3 XPCC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000404 | Loop DNA binding | TAS | molecular_function |
| GO:0000405 | Bubble DNA binding | TAS | molecular_function |
| GO:0000715 | Nucleotide-excision repair, DNA damage recognition | IDA TAS | biological_process |
| GO:0000718 | Nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0003684 | Damaged DNA binding | IDA IEA | molecular_function |
| GO:0003697 | Single-stranded DNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | IDA IEA TAS | biological_process |
| GO:0010224 | Response to UV-B | IEA | biological_process |
| GO:0031573 | Intra-S DNA damage checkpoint | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0071942 | XPC complex | IDA | cellular_component |
| GO:1901990 | Regulation of mitotic cell cycle phase transition | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0157840052 | 0.9843362448 | 0.3109908003 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8276304899 |
| GSE13712_SHEAR | Down | -0.1216300948 |
| GSE13712_STATIC | Up | 0.2936729266 |
| GSE19018 | Up | 0.3647931265 |
| GSE19899_A1 | Up | 0.0132184186 |
| GSE19899_A2 | Up | 0.4232870452 |
| PubMed_21979375_A1 | Up | 0.0713815060 |
| PubMed_21979375_A2 | Up | 1.3008874053 |
| GSE35957 | Down | -0.1036392379 |
| GSE36640 | Up | 0.0452912661 |
| GSE54402 | Up | 0.0151467219 |
| GSE9593 | Down | -0.1318604069 |
| GSE43922 | Up | 0.0522987659 |
| GSE24585 | Up | 0.5135275150 |
| GSE37065 | Up | 0.0914882520 |
| GSE28863_A1 | Up | 0.5963326873 |
| GSE28863_A2 | Up | 0.3166256883 |
| GSE28863_A3 | Up | 0.4154245788 |
| GSE28863_A4 | Up | 0.0189592968 |
| GSE48662 | Up | 0.3375165264 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020495 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050279 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
